慢性阻塞性肺病、慢性肺原性心脏病患者白细胞粘附功能的研究  

Study the Function of Leukocyte Adhesion in the COPD and the Chronic Cor Pulmonale

作　　者：陈宇洁[1] 彭香[1] 陆海英[1] 赵杰[1] 万晓兵[1] 雷松[2] 周东[2] 

机构地区：[1]四川省第四人民医院,四川成都610016 [2]华西医科大学附属第一医院,四川成都610041

出　　处：《华西医学》2001年第1期105-106,共2页West China Medical Journal

基　　金：四川省科委重点科学技术研究基金资助项目!(97- 0 1 4 )

摘　　要：目的 :探讨慢阻肺、肺心病患者白细胞与正常内皮细胞粘附特点。方法 :采用流室系统对正常人、慢阻肺、肺心病患者血白细胞与正常内皮细胞粘附特性进行研究。结果 :慢阻肺及肺心病患者组血白细胞粘附率较正常组明显增强 (P <0 0 5 ) ;肺心病组的白细胞粘附率较慢阻肺组亦有显著性增强 (P <0 0 5 )。结论 :白细胞粘附作用的增强在慢阻肺、肺心病的发病过程中起了重要作用。Objective:Study the adhesion characters between the leukocytes and the normal endothelium cells in the COPD and the Cor pulmonale patients.Methods:By flow chamber system,study the adhesion characters between the leukocytes and the normal endothelium cells respectively in normal,COPD and Cor pulmonale patients.Results:Leukocytes adhesion rates are significantly increased in the COPD group and the Cor pulmonale group than the normal one( P <0 05),and leukocyte adhesion rate in the Cor pulmonale group is much higher than the COPD group ( P <0 05).Conclusion:Increase of the adhesion between the leukocytes plays an important role in the pathogenesis of COPD and of Cor pulmonale.

关 键 词：慢性阻塞性肺病 慢性肺原性心脏病 白细胞粘附 内皮细胞粘附 

分 类 号：R541.5[医药卫生—心血管疾病]