维生素D对毛细支气管炎患儿血清瘦素、T细胞亚群的影响及意义  

The Effects and Significance of Vitamin D on Serum Leptin and T Lymphocyte Subpoputation in Children with Bronchiolitis

作　　者：程玉先[1] 陈欣欣[1] 杨静[1] 

机构地区：[1]聊城市人民医院儿科,山东聊城252000

出　　处：《中外医疗》2014年第15期15-16,19,共3页China & Foreign Medical Treatment

摘　　要：目的探讨维生素D对毛细支气管炎患儿瘦素、T细胞亚群的影响及意义。方法检测64例毛细支气管炎患儿血清维生素D、瘦素、T细胞亚群,其中30例维生素D检测结果偏低患儿,给予维生素D治疗,30 d复查,与对照组比较。结果 64例毛细支气管炎患儿维生素D、CD3(%)、CD8(%)水平显著低于对照组(P<0.05),而瘦素、CD4(%)、CD4/CD8显著高于对照组(P<0.05);治疗30 d时患儿维生素D、CD3(%)、CD8(%)显著升高(P<0.05),瘦素、CD4/CD8显著下降(P<0.05),CD4虽有下降,但与治疗前差异无统计学意义(P>0.05)。结论维生素D和瘦素参与了毛细支气管炎患儿免疫调节,对于毛细支气管炎患儿适量补充维生素D,能够改善患儿免疫状态。Objective To investigate the effects and significance of oral vitamin D on serum leptin and T lymphocyte subpoputation in children with bronchiolitis. Methods The serum vitamin D level, leptin level and T lymphocyte subpoputation of 64 cases of in-fants with bronchiolitis were detected. Of whom, 30 cases who had lower vitamin D level were given the treatment of vitamin D. 30 days after the treatment, the vitamin D level, leptin level and T lymphocyte subpoputation of the patients were redetected, and the detection results were compared with those of the control group. Results The level of vitamin D, CD3 （%）, CD8 （%） of 64 infants with bronchiolitis was significantly lower than that of the control group （ P〈0.05）, but significantly higher in leptin, CD4 （%）, CD4/CD8（P〈0.05）. After 30 days of treatment, the level of vitamin D, CD3（%）, CD8（%） significantly elevated （P〈0.05） and the level of leptin, CD4/CD8 significantly decreased, compared with the beginning of the treatment （ P〈0.05）; although the level of CD4 de-creased, compared with that before the treatment, the difference was not statistically significant （ P〉0.05）. Conclusion Vitamin D and leptin take part in the immune regulation mechanism of bronchiolitis. For children with bronchiolitis, intaking moderate vita-min D can improve the immune state of these children.

关 键 词：瘦素 T细胞亚群 毛细支气管炎 

分 类 号：R725[医药卫生—儿科]