Ephrin-B2/EphA4 forward signaling is required for regulation of radial migration of cortical neurons in the mouse  

作　　者：Yan Hu Sen Li Hua Jiang Ming-Tao Li Jia-Wei Zhou 

机构地区：[1]Department of Pharmacology and Proteomics Center, Zhongshan School of Medicine, Sun Yat-Sen University [2]Institute of Neuroscience, State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences

出　　处：《Neuroscience Bulletin》2014年第3期425-432,共8页神经科学通报（英文版）

基　　金：supported by grants from the Chinese Academy of Sciences;the National Basic Research Development Program of China (2011CB504102);the National Natural Science Foundation of China (31123002 and 31321091)

摘　　要：Postmitotic neurons in the neocortex migrate to appropriate positions and form layered structures of nascent cortex during brain development. The migration of these neurons requires precise control and coordination of a large number of molecules such as axon guidance cues. The Eph-ephrin signaling pathway plays important roles in the development of the nervous system in a wide variety of ways, including cell segregation, axon pathfinding, and neuron migration. However, the role of ephrin-B2/ EphA4 signaling in cortical neuron migration remains elusive. Here we demonstrated that ephrin-B2 and its receptor EphA4 were expressed in complementary and overlapping patterns in the developing neocortex. Deletion of the EphA4 gene in the embryonic cerebral cortex resulted in faster migration of cortical neurons, whereas knockdown or overexpression of ephdn-B2 did not alter the normal process of migration. These results suggest that ephrin-B2 forward signaling through EphA4 is required for the precise control of cortical neuron migration.Postmitotic neurons in the neocortex migrate to appropriate positions and form layered structures of nascent cortex during brain development. The migration of these neurons requires precise control and coordination of a large number of molecules such as axon guidance cues. The Eph-ephrin signaling pathway plays important roles in the development of the nervous system in a wide variety of ways, including cell segregation, axon pathfinding, and neuron migration. However, the role of ephrin-B2/ EphA4 signaling in cortical neuron migration remains elusive. Here we demonstrated that ephrin-B2 and its receptor EphA4 were expressed in complementary and overlapping patterns in the developing neocortex. Deletion of the EphA4 gene in the embryonic cerebral cortex resulted in faster migration of cortical neurons, whereas knockdown or overexpression of ephdn-B2 did not alter the normal process of migration. These results suggest that ephrin-B2 forward signaling through EphA4 is required for the precise control of cortical neuron migration.

关 键 词：neuron migration Eph receptor A4 ephrin-B2 cerebral cortex development 

分 类 号：R338[医药卫生—人体生理学]