Protein kinase D: a new player among the signaling proteins that regulate functions in the nervous system  

作　　者：Gang Li Yun Wang 

机构地区：[1]Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Key Laboratory for Neuroscience, Ministry of Education/National Health and Family Planning Commission, Peking University [2]PKU-IDG/McGovern Institute for Brain Research, Peking University

出　　处：《Neuroscience Bulletin》2014年第3期497-504,共8页神经科学通报（英文版）

基　　金：supported by the National Natural Science Foundation of China (81161120497, 30925015, 30830044, 30900582, and 81221002);the National Basic Research Development Program (973 Program) of China (2014CB542204)

摘　　要：Protein kinase D （PKD） is an evolutionarily-conserved family of protein kinases. It has structural, regulatory, and enzymatic properties quite different from the PKC family. Many stimuli induce PKD signaling, including G-protein-coupled receptor agonists and growth factors. PKD1 is the most studied member of the family. It functions during cell proliferation, differentiation, secretion, cardiac hypertrophy, immune regulation, angiogenesis, and cancer. Previously, we found that PKD1 is also critically involved in pain modulation. Since then, a series of studies performed in our lab and by other groups have shown that PKDs also participate in other processes in the nervous system including neuronal polarity establishment, neuroprotection, and learning. Here, we discuss the connections between PKD structure, enzyme function, and localization, and summarize the recent findings on the roles of PKD-mediated signaling in the nervous system.Protein kinase D （PKD） is an evolutionarily-conserved family of protein kinases. It has structural, regulatory, and enzymatic properties quite different from the PKC family. Many stimuli induce PKD signaling, including G-protein-coupled receptor agonists and growth factors. PKD1 is the most studied member of the family. It functions during cell proliferation, differentiation, secretion, cardiac hypertrophy, immune regulation, angiogenesis, and cancer. Previously, we found that PKD1 is also critically involved in pain modulation. Since then, a series of studies performed in our lab and by other groups have shown that PKDs also participate in other processes in the nervous system including neuronal polarity establishment, neuroprotection, and learning. Here, we discuss the connections between PKD structure, enzyme function, and localization, and summarize the recent findings on the roles of PKD-mediated signaling in the nervous system.

关 键 词：PKD neuronal polarity pain modulation NEUROPROTECTION learning 

分 类 号：R741[医药卫生—神经病学与精神病学]