轮状病毒感染相关受体的研究进展  

Research Progress in Receptors Involved in Rotavirus Infection

作　　者：马鑫[1,2] 李丹地[2] 李秀萍[3] 段招军[2] 

机构地区：[1]宁夏医科大学检验学院,银川750004 [2]中国疾病预防控制中心病毒病预防控制所,北京102206 [3]宁夏医科大学总医院,银川750004

出　　处：《病毒学报》2014年第3期303-309,共7页Chinese Journal of Virology

摘　　要：轮状病毒是引起婴幼儿腹泻的主要病原体之一,由三层同心的蛋白质衣壳包被双链RNA基因组构成。轮状病毒感染宿主细胞主要依赖于病毒识别细胞表面的特异性受体并与其发生结合,因此,受体是病毒感染细胞的重要因素。目前已发现的受体包括唾液酸、整合素、Toll样受体、血型组织抗原等,本文将对参与轮状病毒感染的相关受体作一简要概述。Rotaviruses, which are recognized as one of the children with diarrhea, consist of three concentric layers major etiological agents among infants and young of protein capsid with the enclosed double-stranded RNA genome. Rotaviruses infect host cells mainly by identifying the specific receptors on cell surfaces and binding to them. Therefore, receptors are important factors for viruses infecting ceils. So far, there have been many receptors found to be involved in rotavirus infection, including sialic acid, integrin, Tolllike receptor, and blood group antigen. This article provides an overview of receptors involved in rotavirus infection.

关 键 词：轮状病毒 受体 细胞黏附 唾液酸 整合素 TOLL样受体 血型组织 

分 类 号：R373.9[医药卫生—病原生物学]