冠状病毒附属基因功能研究  

Research Progress in Functions of Coronavirus Accessory Genes

作　　者：杨扬[1] 谭文杰[1] 

机构地区：[1]中国疾病预防控制中心病毒病预防控制所,北京102206

出　　处：《病毒学报》2014年第3期325-332,共8页Chinese Journal of Virology

基　　金：国家973课题(2011CB504704);传染病重大专项(2011ZX10004-001)

摘　　要：除了S、E、M、N等结构基因以外,冠状病毒的基因组还包括数量不等的附属基因,称为"组特异性基因或者附属基因",这些基因编码的产物被命名为"附属蛋白"。研究发现,对于大多数冠状病毒来说,这些附属基因所编码的蛋白对病毒的体外复制不是必须的;但是在自然选择的压力下,许多附属基因仍然保留在冠状病毒基因组中,表明它们对于病毒在宿主的天然环境中生存扮演了非常重要的角色。本文就冠状病毒附属基因功能就研究进展简要综述。In addition to the structural genes of the coronavirus genome, S, E, M, and N, there are several additional genes called ＂group-specific or accessory genes＂. Their gene products are designated as ＂accessory proteins＂, as reports to date make it clear that these proteins are not essential for virus replication in vitro. Nevertheless, many of these genes are still maintained in the virus genome under selective pressure, suggesting that they might play a very important role in the survival of the virus in the natural environment of the infected host. This review will summarize the research progress in the functions of coronavirus accessory genes.

关 键 词：冠状病毒 附属基因 功能 

分 类 号：R373.9[医药卫生—病原生物学]