重组人促红细胞生成素与铁剂联合治疗早产儿贫血的效果  

Effect of recombilmnt human erythropoietin combined with iron on anemia in premature newborn

作　　者：夏晓芹[1] 阳红华[1] 唐上可 张志刚[1] 赖宝添 卢庆晖[1] 

机构地区：[1]中山大学附属东华医院,广东东莞523110

出　　处：《中国实用医刊》2014年第13期18-19,共2页Chinese Journal of Practical Medicine

摘　　要：目的观察重组人促红细胞生成素（EPO）与铁剂联合治疗早产儿贫血的效果。方法选取2012年1月至2013年11月东华医院新生儿科收治的早产儿贫血患儿52例，治疗组28例，对照组24倒。治疗组给予人促红细胞生成素与铁剂联合连续治疗3周，对照组按常规方法治疗。对两组患儿治疗1周及3周后的结果进行统计学分析。结果治疗组组内比较，治疗7d、21d后EPO、网织红细胞（Ret）水平较治疗前增加，差异有统计学意义（P〈0．01）；治疗21d后红细胞计数（RBC）、血细胞比容（HCT）、血红蛋白（Hb）水平较治疗前增加．差异有统计学意义（P〈0．05）。治疗组与对照组组间比较，治疗21d后RBC、HCT、Hb、EPO、Ret水平差异有统计学意义（P〈0．05）。结论应用重组人促红细胞生成素与铁剂联合早期干预治疗新生儿贫血的临床效果较好，能有效减少输血或避免输血，且用药安全，接近生理途径，值得推广。Objective To observe the effects of recombinant human erythropoietin combined with iron on anemia in premature newborn. Methods From January 2012 to November 2013, 52 cases of anemia in premature newborn in our hospital were chose, including 28 patients in the treatment group and 24 patients in the control group. Patients in the treatment group received recombinant human erythro- poietin combined with iron for 3 weeks, and the patients in the control group received conventional meth- ods. The results of the two groups after 1 week and 3 weeks of treatment were statistically analyzed. Re- sults In treatment group, after 7 days and 21 days of treatment, the levels of EPO and reticulocyte were higher than those before treatment, the differences were significant（P 〈0. 01 ） ; after 21 days of treatment, the levels of RBC, HCT, Hb were higher than those before treatment, the differences were significant （P 〈 0. 05 ）. There were significant differences in the levels of RBC, HCT, Hb, EPO, Ret after 21 days of treat- ment between the two groups （P 〈 0. 05）. Conclusions The clinical effect of recombinant human erythro- poietin combined with iron on early intervention of neonatal anemia is good and safe, it can effectively re- duce or avoid blood transfusions, and is close to the physiological pathways, so is worthy of promotion.

关 键 词：促红细胞生成素(EPO) 早产儿 贫血 

分 类 号：R722.6[医药卫生—儿科]