开放性骨折术后铜绿假单胞菌感染及耐药性分析  

An analysis of pseudomonas aeruginosa infection and drug resistance after operation on open fractures

作　　者：许玉兵 章可谓[2] 葛丹枫[2] 

机构地区：[1]浙江中医药大学附属富阳中医骨伤医院,浙江富阳311400 [2]浙江省富阳市中医医院,浙江富阳311400

出　　处：《健康研究》2014年第3期254-255,共2页Health Research

摘　　要：目的了解开放性骨折术后铜绿假单胞菌感染及耐药性,指导抗菌药物合理使用。方法对开放性骨折术后患者标本培养分离的铜绿假单胞菌药敏试验结果进行分析。结果共送检标本3796份,检出病原菌2845株,其中铜绿假单胞菌401株(14.1%);药敏试验结果显示:铜绿假单胞菌对阿米卡星、依替米星、亚胺培南的耐药性分别为22.7%、23.1%、34.7%;对头孢哌酮·舒巴坦、头孢他啶、头胞吡肟、环丙沙星的耐药性分别为40.4%、42.9%、47.1%、48.9%;对哌拉西林·他唑巴坦的耐药性为50.1%;对头孢曲松、头孢噻肟、左氧氟沙星的耐药性分别为73.1%、89.3%、90.0%;对氨苄西林的耐药性为100%。结论铜绿假单胞菌的耐药性已经十分突出,应积极开展病原菌检查,根据药敏试验合理使用抗菌药物。Objective To understand the phenomenon of pseudomonas aeruginosa infection and drug resistance after operation on open fractures so as to develop scientific knowledge for effective use of antimicrobial drugs. Method Drug susceptibility tests were conducted on the culture specimens obtained from patients having operation on open fractures during July 2012 and July 2013. 401 strains of pseudomonas aeruginosa were developed. The test results were then analyzed. Findings 2845 strains of pathogenic bacteria were detected out of the 3796 samples,in which 401 were strains of pseudomonas aeruginosa（ 14. 1%）; Drug susceptibility test results showed that the rates of drug resistance of pseudomonas aeruginosa to amikacin,etimicin and imipenem were 22. 7%,23. 1% and 34. 7% respectively; those to cefoperazone · sulbactam,ceftazidime,Cefpirome,Ciprofloxacin were 40. 4%,42. 9%,47. 1% and 48. 9% respectively; that to piperacillin· tazobactam was 50. 1%; and those to ceftriaxone,cefotaxime,and levofloxacin were 73. 1% 、89. 3% and 90. 0% respectively; and its resistance to ampicillin appeared to be 100%. Conclusion Pseudomonas aeruginosa has considerable drug resistance. Critical examination of pathogenic bacteria should be conducted before use of any antimicrobial agents.

关 键 词：铜绿假单胞菌 抗菌药物 开放性骨折术后 耐药性 

分 类 号：R446.5[医药卫生—诊断学]