瑞舒伐他汀与阿托伐他汀治疗老年高脂血症患者临床疗效的比较  

Curative effect of rosuvastatin and atorvastatin in elderly hyperlipoidemia patients

作　　者：国希云[1] 李晓英[1] 邓娴[1] 陈永秀[1] 阳蒙蒙 李丽娜[1] 戴华[1] 

机构地区：[1]解放军总医院门诊部干部诊疗科,北京100853

出　　处：《中华老年心脑血管病杂志》2014年第6期605-607,共3页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

摘　　要：目的：探讨瑞舒伐他汀治疗老年高脂血症患者的疗效和安全性，并与阿托伐他汀进行比较。方法选择2012年6～12月在我院门诊干部诊疗科就诊的老年患者128例，随机分为瑞舒伐他汀组64例（瑞舒伐他汀5 m g/d）和阿托伐他汀组64例（阿托伐他汀10 mg/d），共治疗8周。2组患者继续原发病的常规治疗，停用其他调脂药物2周，以减少对疗效判断的干扰。结果治疗8周后，瑞舒伐他汀组TC、TG和LDL-C下降幅度分别为25．9％、13．5％和33．7％，阿托伐他汀组下降幅度分别为22．6％、12．1％和31．4％，2组下降幅度比较，差异无统计学意义（P＞0．05）。瑞舒伐他汀组与阿托伐他汀组 HDL-C上升幅度差异有统计学意义（9．7％ vs 3．2％，P＜0．05）。2组患者对药物的依从性好，无药物不良反应。结论瑞舒伐他汀5 mg与阿托伐他汀10 mg在降低TC、TG及LDL-C方面相似；瑞舒伐他汀可提高 HDL-C水平，且在老年患者中两者安全性相同。Objective To compare the efficacy and safety of rosuvastatin and atorvastatin in elderly hyperlipoidemia patients .Methods One hundred and twenty-eight elderly phyperlipoidemia patients who visited our department from from May 2012 to December 2012 were randomly divided into rosuvastatin treatment group （n=64） and atorvastatin treatment group （n=64） .Patients in rosuvastatin treatment group were treated with rosuvastatin （5 mg/d） and those in atorvastatin treatment group were treated with atorvastatin （10 mg/d） for 8 weeks .Primary hyperlipoidemia received conventional therapy with anti-hyperlipoidemia drugs withdrawn for 2 weeks in order to accurately assess the curative effect of rosuvastatin and atorvastatin .Results No significant difference was found in serum levels of TC ,LDL-C and TG ,although they were lower in rosuvastatin treatment group than in atorvastatin treatment group after 8-week treatment （25 .9% vs 22.6% ,33 .7% vs 31 .4% ,13 .5% vs 12 .1% ,P〉0 .05） .The serum HDL-C level was significantly higher in rosuvastatin treatment group than in atorvastatin treatment group （9 .7% vs 3 .2% ,P〈0 .05） .The drug dependence was good in two groups with no adverse event .Conclusion The efficiency and safety of rosuvastatin （5 mg/d） and atorvastatin （10 mg/d） are similar in reducing the serum levels of TC ,TG ,LDL-C ,and rosuvastatin can increase the serum HDL-C level in elderly hyperlipoidemia patients .

关 键 词：高脂血症 降血脂药 羟甲基戊二酰基COA还原酶抑制剂 

分 类 号：R589.2[医药卫生—内分泌]