呼出气一氧化氮测定在老年哮喘诊治中的应用研究  

The value of fractional exhaled nitric oxide detection in the diagnosis and treatment of asthma in senile patients

作　　者：张树荣[1] 胡剑超[1] 袁丽[1] 崔盼盼[1] 郭守福 李小梅[1] 杨清霞[1] 

机构地区：[1]成都军区昆明总医院北较场病区综合内科,昆明650032

出　　处：《西南国防医药》2014年第6期594-596,共3页Medical Journal of National Defending Forces in Southwest China

摘　　要：目的：探讨呼出气一氧化氮（ FeNO）测定在老年哮喘诊治中的应用价值。方法对我院在2013年3月-2014年2月收治的38例老年支气管哮喘患者进行FeNO检测，并与同期收治的38例非呼吸系统疾病老年患者进行比较。结果治疗前哮喘组FeNO[（59.2±16.8）ppb]显著高于对照组[（18.6±6.1）ppb]（P﹤0.01）；哮喘组FeNO在治疗3 d后[（51.5±13.7）ppb]和出院时[（36.1±9.4）ppb]，均较治疗前明显下降（ P﹤0.05或P﹤0.01），但仍显著高于对照组（ P﹤0.01）。对16例哮喘患者在出院3个月后进行随访，其FeNO为（27.3±8.2）ppb，较出院时明显下降（ P﹤0.01），但也仍高于对照组（ P﹤0.01）。结论 FeNO在老年哮喘患者中明显增高，FeNO检测对老年哮喘的诊治有很好的指导作用。Objective To investigate the value of fractional exhaled nitric oxide（ FeNO ） detection in the diagnosis and treatment of asthma in senile patients. Methods FeNO detection was performed on 38 senile patients with asthma（ asthma group） hospitalized from March 2013 to February 2014,and another 38 senile patients without respiratory diseases hospitalized within the same period were selected to be the control. Results Before treatment,FeNO in asthma group[（59. 2 ± 16. 8）ppb]was significantly higher than that in control group[（18. 6 ± 6. 1）ppb]（P﹤0. 01）;while it was much lower 3 days after treatment[（51. 5 ± 13. 7）ppb]and at discharge[（36. 1 ± 9. 4）ppb]（P﹤0. 05 or P﹤0. 01）,but still significantly higher than that in control group（P﹤0. 01）;the follow-up made 3 months after discharge found that FeNO in 16 senile patients with asthma had dropped to[（27. 3 ± 8. 2）ppb],much lower than that at their discharge,but still higher than that in control group（P﹤0. 01）. Conclusions FeNO in senile patients with asthma increases significantly and FeNO detection is of great value in the diagnosis and treatment of asthma in senile patients.

关 键 词：支气管哮喘 呼出气一氧化氮 老年 诊断 治疗 FRACTIONAL exhaled NITRIC oxide( FeNO) 

分 类 号：R562.25[医药卫生—呼吸系统]