川乌抗肿瘤初步研究  

Preliminary study of Radix Aconiti on anti-tumor

作　　者：黄秀曼[1,2] 刘迎辉[2] 杜钢军[2] 

机构地区：[1]南阳市第一人民医院临床医学科,河南南阳473000 [2]河南大学药学院药物研究所,河南开封475004

出　　处：《河南大学学报（医学版）》2014年第2期82-84,共3页Journal of Henan University:Medical Science

基　　金：国家自然科学基金项目(81173094);河南省高校青年骨干教师项目(2010GGJS-025);河南省科技厅重点攻关项目(112101310308);河南大学省部共建项目(SBGJ090704)

摘　　要：目的初步研究川乌的抗肿瘤作用。方法体内实验:建立小鼠肝癌H22皮下移植动物模型,灌胃给药后测定原位肿瘤体积、质量及免疫器官指数;体外实验:用MTT法测定川乌对小鼠Lewis肺癌细胞增殖的影响。结果体内实验:在本实验剂量下,与模型组比较,川乌组肿瘤生长减缓,抑瘤率为32.05﹪,胸腺指数、脾脏指数均升高;体外实验:实验所用浓度的川乌对小鼠肺癌细胞有生长抑制作用。结论川乌有一定抗肿瘤作用。Objective To study the anti-tumor of Radix Aconiti preliminarily . MethodsIn vivo , the model of H22 liver cancer was established to observe anti-tumor by measuring the volume , weight of in situ tumor and immune organs index after ig of Radix Aconiti medicinal liquor . In vitro , the effects of Radix Aconiti medicinal liquor on Lewis cells by MTT assay .Results In vivo , compared with the model group , the tumor in Radix Aconiti group was smaller , the tumor inhibitory rate was 32 .05% , both of thymus index and spleen index increased .In vitro ,Radix Aconiti medicinal liquor at used doses inhibited proliferation of lewis lung cancer cells . Conclusion Radix Aconiti medicinal liquor has beneficial effects on tumor treatment .

关 键 词：川乌 H22 LEWIS MTT 

分 类 号：R285.5[医药卫生—中药学]