丹参抗抑郁作用新探  

Analysis for the antidepressant effect of radix salvia miltiorrhiza

作　　者：潘菊华[1] 王彦云[1] 张永超[1] 霍蕊莉[2] 

机构地区：[1]中国中医科学院广安门医院中药研发中心,北京100053 [2]中国中医科学院科研管理处

出　　处：《环球中医药》2014年第6期488-491,共4页Global Traditional Chinese Medicine

基　　金：国家自然科学基金(81072801);北京市自然科学基金(7093129);北京市中医管理局中医药科技项目(JJ2011-84)

摘　　要：本文旨在探讨丹参抗抑郁作用及其可能机制。丹参作为心脑血管疾病常用中药,在临床抗抑郁治疗中应用频次很高,其脂溶性有效成分丹参酮类化合物及水溶性有效成分丹酚酸等具有良好的抗氧化、改善微循环、神经保护、内分泌调控等作用,针对抑郁症发生的氧化应激、神经损伤和内分泌紊乱等可能机制具有改善作用。丹参在抑郁症中的作用值得进一步研究。This paper aims to explore possible mechanisms of the antidepressant effect of Radix salvia miltiorrhiza. Radix salvia miltiorrhiza, a commonly Chinese material medica for heart and cerebral vessel diseases, was frequently applied as antidepressant frequently in clinical. . The fat soluble effective components （tanshinone compounds） and the water soluble effective components （salvianolic acid） have effect of antioxidative, microcirculation improving, neuroprotective and endocrine regulation effects, which could improve the possible mechanisms of depression including oxidative stress, injury of nerve and endo-crine disorders. The role of radix salvia miltiorrhiza in depression deserves the further study.

关 键 词：丹参 抑郁症 血管性抑郁 丹参酮 丹酚酸 

分 类 号：R285[医药卫生—中药学]