稳定型冠心病合并不同糖代谢状态患者中甲状腺激素测定的意义  

Significance of determination of serum thyroid hormonens of stable coronary heart disease patients in different glucose metabolic statuses

作　　者：张月娥 王楠[2] 周淑红[3] 

机构地区：[1]安定区第二人民医院内科,甘肃定西743000 [2]甘肃省人民医院心血管内科,甘肃兰州730000 [3]甘肃省人民医院糖尿病内分泌科,甘肃兰州730000

出　　处：《国际检验医学杂志》2014年第11期1402-1404,共3页International Journal of Laboratory Medicine

摘　　要：目的探讨甲状腺激素水平在稳定型冠心病合并不同糖代谢状态的患者中的意义。方法采用电化学发光法检测173例稳定型冠心病合并不同糖代谢状态的患者和58例健康对照者血中甲状腺激素水平,所有研究者均行75g葡萄糖粉口服试验评价糖代谢情况和胰岛素抵抗指数。结果甲状腺激素、收缩压、舒张压和胰岛素抵抗指数在稳定型冠心病合并不同糖代谢状态患者中的差异均无统计学意义(P>0.05)。稳定型冠心病合并2型糖尿病组患者的空腹血糖、餐后2h血糖和糖化血红蛋白高于稳定型冠心病合并糖耐量减退和正常糖耐量组,差异均有统计学意义(P<0.05)。稳定型冠心病合并糖耐量减退组患者的餐后2h血糖高于稳定型冠心病合并正常糖耐量组和健康对照组,差异均有统计学意义(P<0.05)。结论血清甲状腺激素水平可能不是参与冠心病合并糖尿病发病机制的影响因素。Objective To evaluate the importance of serum thyroid hormonens level of patients with stable coronary heart disease（CAD）in different glucose metablic statuses.Methods 173 cases of CAD patients in different glucose metablic statuses and 58 cases of healthy people were enrolled in the study.The levels of thyroid hormonens and serum insulin was measured by electro-chemiluminescence,and the evaluation of glucose metablic statuses and insulin resistance index was by means of 75 g oral glucose tolerance test.Results There was no significant difference in the levels of systolic pressure（SBP）,diastolic pressure（DBP）,insulin resistence index and serum thyroid hormonens among CAD patients with different glucose metablic statuses（P 〉0.05）.The levels of fasting plasma glucose,2 hour postprandial plasma glucose（PG2h）and glycosylated hemoglobin（HbA1c）in CAD complicated with type 2 diabetes group were significantly higher than those in CAD complicated with impaired glucose tolerance group and CAD complicated with normal glucose tolerance group （P 〈 0.05 ）.And the PG2h level of CAD complicated with impaired glucose tolerance group was significantly higher than both of CAD complicated with normal glucose tolerance group and normal control group s（P 〈0.05）.Conclusion It indicates that serum thyroid hormonens level may not affect glycometabolism in CAD patients.

关 键 词：甲状腺激素 冠心病 糖代谢 

分 类 号：R587.1[医药卫生—内分泌] R541.4[医药卫生—内科学]