前列癃闭通胶囊对大鼠前列腺增生影响的实验研究  

The influence of forefront uroschesis tong capsule on prostatic hyperplasia of rats

作　　者：马合苏提[1] 靳宏勇[1] 唐泽天[1] 

机构地区：[1]新疆维吾尔自治区人民医院泌尿中心四科,乌鲁木齐830001

出　　处：《中国医药》2014年第7期1040-1042,共3页China Medicine

摘　　要：目的观察前列癃闭通胶囊对大鼠前列腺增生的影响, 为临床中药治疗前列腺增生提供依据。方法取SD雄性2个月龄大鼠30只, 完全随机分成正常对照组、模型组和前列癃闭通治疗组各10只。 应用去势大鼠皮下注射丙酸睾丸酮诱导前列腺增生, 观察正常对照组、模型组、前列癃闭通组大鼠前列腺的湿重、前列腺指数、酸性磷酸酶的变化。结果前列癃闭通组大鼠前列腺的湿重（375±58）mg、前列腺指数（1.68±0.22）和酸性磷酸酶（5.6±1.2）均明显低于模型组［湿重：（419±53）mg； 前列腺指数： 2.11±0.19；酸性磷酸酶：（8.2±1.3）U/L］，差异有统计学意义（P〈0. 01），并接近正常组的数值［湿重：（321±20）mg；前列腺指数： 1.08±0.12；酸性磷酸酶：（5.1±0.1）U/L］。结论前列癃闭通胶囊可明显抑制大鼠前列腺增生, 抑制大鼠血清酸性磷酸酶水平升高，临床上可以利用中药前列癃闭通胶囊治疗良性前列腺增生症。ObjectiveTo observe influence of Top uroschesis tong capsule on prostatic hyperplasia of rats. MethodsA total of 30 of 2 month olds male rats were assigned randomly into normal control group（n=10）, model group（n=10） and topuroschesis treatment group（n=10）. The prostate hyperplasia of castrated rats was induced by subcutaneous testosterone propionate; the changes of wet weight, prostatic index, acid phosphatase （ACP） of rat prostate in each group were analyzed.ResultsWet weight was （375±58） mg; prostate index was 1.68 ± 0.22 and acid phosphatase was 5.6±1.2 in topuroschesis treatment group; wet weight was （419±53）mg; prostate index was 2.11 ± 0.19; acid phosphatase was 8.2±1.3; there was a significant difference in both groups （P〈0 01）, and there was no difference between in the topuroschesis treatment group and in the normal control group [ wet weight ： （321 ± 20） mg; prostate index ： 1.08 ± 0.12 ; acid phosphatase： 5.1±0.1]. ConclusionsForefront uroschesis tong capsule can inhibit prostate hyperplasia and the increased levels of serum acid phosphatase in rats.

关 键 词：前列腺增生 中医药治疗 前列癃闭通 酸性磷酸酶 

分 类 号：R697[医药卫生—泌尿科学]