医用水凝胶在激光治疗中的应用及多中心临床疗效观察  

Multi-center clinical observation of medical hydrogel as cooling dressings application to laser dermatology

作　　者：樊昕[1] 刘丽红[1] 安俞熙[1] 富秋涛[2] 李淼[3] 李远宏[4] 夏文华 李雨璇 杨蓉娅[1] 

机构地区：[1]北京军区总医院全军皮肤损伤修复研究所激光美容中心,北京100700 [2]空军总医院激光美容中心 [3]沈阳军区总医院整形美容中心 [4]中国医科大学第一附属医院皮肤科 [5]海军总医院激光美容中心 [6]中国医学科学院整形外科医院国贸门诊部

出　　处：《实用皮肤病学杂志》2014年第3期193-195,共3页Journal of Practical Dermatology

摘　　要：目的评价医用水凝胶作为冷敷材料在激光治疗术中及术后的临床疗效和安全性。方法国内6家医疗单位随机选取100例患者,其中行强脉冲光治疗52例,激光脱毛治疗26例,色素性疾病22例。采用自身对照,一侧面部(一侧肢体)使用水凝胶,另外一侧作为空白对照。在激光脱毛治疗前将水凝胶贴敷于激光治疗部位,直接透过水凝胶做激光穿透治疗,强脉冲光治疗时用水凝胶替代普通凝胶,其他激光术后将水凝胶贴敷于激光治疗部位。分别于术中、术后30 min和术后7 d观察并评价症状和体征,以及不良反应发生率。结果治疗术中、术后30 min患者和医师评价红斑、灼热、肿胀评分明显降低,水凝胶侧优于对照侧(P<0.05);治疗后30 min临床症状消退评分水凝胶侧明显优于对照侧(P<0.05);术后7 d患者和医师体征评分和临床症状消退评分水凝胶侧与对照侧无差异(P>0.05);无1例患者出现不良反应。结论医用水凝胶在激光治疗中和术后短期内可以有效改善患者不适感和降低激光术后皮肤反应,提高患者依从性和舒适度。ObjectiveTo evaluate the safety, efficacy, and patient acceptance of hydrogel dressings applied in laser dermatology. MethodsOne hundred patients underwent laser dermatology were selected randomly over 6 hospitals in China. The hydrogel dressing was applied to their corresponding treatment skin as cooling material, which laser directly went through. Intense pulsed light therapy in 52 cases, laser hair removal in 26 cases and 22 cases of pigmented diseases were selected. Using self control, half face （side limb） using hydrogel, the other half as blank control. In a hydrogel coated on the laser treatment in site would before treatment, laser hair removal, directly through the hydrogel treatment laser, intense pulsed light in the treatment of water gel instead of conventional gel, other laser surgery would be pasted on the laser treatment in site hydrogel. Respectively during the operation, after 30 minutes and 7 days after operation to observe and evaluate the patient and physician assessment of the incidence of clinical symptoms and signs, doctor VAS score and adverse reactions.ResultsThere were signiifcant difference in the operative＆amp; postoperative criteria of bruises, pain, erythema and swelling between the side of the hydrogel and the control side （P〈0.05）. The score of clinical symptoms after 30 minutes in hydrogel side was better than the control side after treatment （P〈0.05）. There were no signiifcant difference after 7 days between two sides （P〉0.05）. And there were no complications of surface irregularities or contact dermatitis from the application or maintenance of hydrogel dressings.ConclusionsHydrogel dressings are safe and effective to reduce side effects of laser dermatology and patients are compliant with overall acceptance.

关 键 词：水凝胶 冷敷 皮肤反应 激光治疗 

分 类 号：R318.08[医药卫生—生物医学工程] R616.4[医药卫生—基础医学]