丁苯酞联合依达拉奉治疗一氧化碳中毒迟发性脑病临床疗效观察  

Study on effect of NBP combined with edaravone in treating with DEACMP

作　　者：张芳芳[1] 周俐红[1] 周海燕[1] 

机构地区：[1]河南省新乡市中心医院神经内二科,河南新乡453000

出　　处：《中国伤残医学》2014年第12期20-22,共3页Chinese Journal of Trauma and Disability Medicine

摘　　要：目的：探讨丁苯酞联合依达拉奉治疗一氧化碳中毒迟发性脑病患者的临床疗效。方法：30例对照组患者应用高压氧治疗，改善脑循环；促进脑细胞代谢，如胞二磷胆碱或乙酰谷酰胺、醒脑静注射液及对症支持和康复功能训练。30例治疗组在此基础上再联合丁苯酞和依达拉奉治疗。治疗前、治疗后1个月分别测定日常生活能力（BI）、长谷川痴呆量表（HDS），比较2个量表数值的变化。并于治疗1个月后判定临床疗效。结果：入院时2组患者BI、HDS评分无显著性差异（P〉0．05）。治疗1个月后，2组BI、HDS评分均有不同程的提高，治疗组评分提高更明显（P〈0．05）。2组治疗1月后临床疗效，治疗组总有效率86．67％，对照组60．00％，治疗组疗效明显优于对照组（P〈0．05）。结论：丁苯酞联合依达拉奉是治疗一氧化碳中毒迟发性脑病可行的治疗方案之一。Objective： To explore effect of dl - 3 - n - butyl phthalide （NBP） combined with edaravone in treating with delayed encephalopathy after acute carbon monoxide poisoning （DEACMP）. Methods：30 cases of the control group of patients treated with hyperbaric oxygen and brain cell activator and other conventional treatment, 30 cases of patients in the treatment group in the conventional treatment on the basis of further joint NBP and edaravone treatment. Before treatment, 1 months after treatment respectively for evaluation of activi-ties of daily living （BI）, Kyohko Hasegawa Dementia Scale （HDS）, comparing the 2 scale values change; clinical evaluation. Results： There was not significant difference in two groups by BI and lIDS prior treatment（P 〉0.05）. There was an increase in two groups by BI and HDS after 1 month treatment,and those in the treatment group had improved further. After 1 month treatment ,the total effective rate in the treatment group（ 86.67% ）was higher than that in the control group（60.00% ） （P 〈 0.05 ）. Conclusion： NBP combined with edaravone might be one of the treatment regimen in the treatment of DEACMP of feasible.

关 键 词：一氧化碳中毒迟发性脑病 丁苯肽 依达拉奉 

分 类 号：R595.1[医药卫生—内科学]