晚期癌症患者生活质量量表EORTC QLQ-C15-PAL中文版有效性的评价  

The validation of the standard Chinese version of EORTC QLQ-C15-PAL in terminal cancer patients

作　　者：罗志芹 王宁[2] 刘家浩[2] 焦杰[1] 武景莲[1] 贾兰宁 吴美静 张雷[1] 

机构地区：[1]天津医科大学附属肿瘤医院,300060 [2]中南大学湘雅医学院 [3]天津医科大学基础医学院

出　　处：《中国实用护理杂志》2014年第13期20-25,共6页Chinese Journal of Practical Nursing

摘　　要：目的 验证EORTC QLQ-C15-PAL量表中文版本的有效性,进一步确定这一工具能否用于衡量中国大陆地区接受姑息治疗的晚期癌症患者的生活质量.方法 以2013年5～8月在天津肿瘤医院接受姑息性治疗的187例晚期癌症患者为对象,让其参与完成量表EORTC QLQ-C30的问卷调查,从中提取EORTC QLQ-C15-PAL量表进行分析,并且让主治医师对患者进行ECOG PS评分及精神状态评定.结果 共187例患者完成了问卷,各个问题的缺失率为0％～2.7％,显示患者依从度很高.除情绪功能外,其余各维度信度均较好（Cronbachα＞0.7）;按照ECOGPS评分将患者分为2组,结果显示2组间评分比较差异有统计学意义;按照精神状态评定将患者分为3组,结果显示3组间评分比较差异有统计学意义;这表明EORTC QLQ-C15-PAL量表能够很好地区分上述分组.本次调查的癌症患者总体生活质量除了与疲乏维度成中度相关外（r=-0.406）,与其他维度均为弱相关.决定系数R2为0.838-0.906,表明QLQ-C1S-PAL能够解释83.8％到90.6％的QLQ-C30.结论 EORTC QLQ-C15-PAL量表中文版有较高的信度和效度,适合在中国进行临床推广以测定晚期癌症患者生命质量.Objective This study evaluated the validity and reliability of the standard Chinese version of the EORTC QLQ-c15- PAL （The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 15 palliative ） to determine if this tool can be used to evaluate Chinese patients with cancer who receive palliative care. Methods In May to August 2013, 187 patients with ad- vanced cancer who received palliative treatment in Tianjin Cancer Hospital completed the questionnaires of EORTC QLQ- c30. We extracted QLQ- c15- PAL data for analysis. The doctor-in- charge assessed the ECOG PS score and the mental state of these patients. Results A total of 187 patients completed the study. The compliance rate was high, with the missing rate for each item ranging from 0 to 2.7%. Three of four multi-item-scale correlations showed Cronbach α values of 〉0.7. We divided the ECOG perform status into two groups and compared QLQ-c15-PAL subscale scores between these groups. Results showed that the questionnaire discriminated among patient subgroups with different ECOG perform status. Global quality of life was moderately correlated with the fatigue（r=--0.406） but only weakly correlated with other subscales. The proportion of variance （W） ranged from 0.838 to 0.906, which showed that QLQ-C15-PAL subscale scores could explain between 83.8% and 90.6% of the original QLQ-c30. Conclusions The Chinese version of the EORTC QLQ-C15-PAL questionnaire has higher reliability and validity, which is suitable for clinic promotion in China to determine HRQL in Chinese patients with terminal cancer.

关 键 词：晚期癌症 姑息治疗 EORTC QLQ-C15-PAL 

分 类 号：R473.73[医药卫生—护理学]