Supramolecular Micelles and Reverse Micelles Based on Cyclodextrin Polyrotaxanes  

作　　者：Qiao Jin Gongyan Liu Jian Ji 

机构地区：MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, China Email: Jian Ji ([e-mail])[*]MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, China, Tel.: [phone] Fax: [phone]

出　　处：《Chinese Journal of Chemistry》2014年第1期73-77,共5页中国化学（英文版）

基　　金：Financial support from the National Natural Science Foundation of China (Nos.51333005,51103126,21374095,51303154) and the Fundamental Research Funds for the Central Universities (No.2013QNA4047)is gratefully acknowledged.

摘　　要：A new supramolecular self-assembly approach to construct micelles and reverse micelles was reported.Double-hydrophilic block copolymers poly(ethylene oxide)-b-poly(N-isopropylacrylamide) (PEO-b-PNIPAAm) was synthesized via atom transfer radical polymerization (ATRP) using PEO macroinitiator.Because of the lower critical solution temperature (LCST) phase behavior of PNIPAAm,PEO-b-PNIPAAm block copolymers self-assembled to form PNIPAAm-core micelles at 40 ℃.The PNIPAAm-core micelles were disassembled to unimers when the temperature was decreased to 25 ℃.But the addition of α-cyclodextrins (α-CDs) could induce the formation of PNIPAAm-shell micelles because of the 'channel-type' crystallities induced by PEO/α-CDs polyrotaxanes.The assembly and disassembly procedure of micelles and reverse micelles were investigated by dynamic light scattering (DLS),X-ray diffraction (XRD),1H NMR and transmission electron microscopy (TEM).A new supramolecular self-assembly approach to construct micelles and reverse micelles was reported.Double-hydrophilic block copolymers poly(ethylene oxide)-b-poly(N-isopropylacrylamide) (PEO-b-PNIPAAm) was synthesized via atom transfer radical polymerization (ATRP) using PEO macroinitiator.Because of the lower critical solution temperature (LCST) phase behavior of PNIPAAm,PEO-b-PNIPAAm block copolymers self-assembled to form PNIPAAm-core micelles at 40 ℃.The PNIPAAm-core micelles were disassembled to unimers when the temperature was decreased to 25 ℃.But the addition of α-cyclodextrins (α-CDs) could induce the formation of PNIPAAm-shell micelles because of the 'channel-type' crystallities induced by PEO/α-CDs polyrotaxanes.The assembly and disassembly procedure of micelles and reverse micelles were investigated by dynamic light scattering (DLS),X-ray diffraction (XRD),1H NMR and transmission electron microscopy (TEM).

关 键 词：CYCLODEXTRIN POLYROTAXANE reverse micelle SUPRAMOLECULAR 

分 类 号：O6[理学—化学]