Synthesis of β-Cyclodextrin-[60]fullerene Conjugate and Its DNA Cleavage Performance  

作　　者：Jingjing Wang Zhaoheng Zhang Wei Wu Xiqun Jiang 

机构地区：[1]Department of Polymer Science and Engineering, College of Chemistry and Chemical Engineering, Nanjing University, Nanjing, Jiangsu 210093, China [2]College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, China Email: Wei Wu ([e-mail]), Xiqun Jiang ([e-mail])[*]Department of Polymer Science and Engineering, College of Chemistry and Chemical Engineering, Nanjing University, Nanjing, Jiangsu 210093, China, Tel.: [phone]

出　　处：《Chinese Journal of Chemistry》2014年第1期78-84,共7页中国化学（英文版）

基　　金：This study was supported by the Natural Science Foundation of China (Nos.51033002 and 51273090)and the Natural Science Foundation of Jiangsu Province (No.BK2010303).

摘　　要：A water soluble β-cyclodextrin (β-CD) functionalized [60]fullerene (C60-CD) was synthesized.The C60-CD-induced generation of reactive oxygen species (ROS),and DNA-cleavage ability and cytotoxicity of C60-CD were studied upon visible light irradiation,demonstrating that the compound is very promising in the applications of photodynamic therapy.The histological analyses demonstrate that C60-CD has no acute or subacute toxicity to living body.A water soluble β-cyclodextrin (β-CD) functionalized [60]fullerene (C60-CD) was synthesized.The C60-CD-induced generation of reactive oxygen species (ROS),and DNA-cleavage ability and cytotoxicity of C60-CD were studied upon visible light irradiation,demonstrating that the compound is very promising in the applications of photodynamic therapy.The histological analyses demonstrate that C60-CD has no acute or subacute toxicity to living body.

关 键 词：FULLERENE Β-CYCLODEXTRIN DNA-cleavage photodynamic therapy 

分 类 号：U491[交通运输工程—交通运输规划与管理] Q523[交通运输工程—道路与铁道工程]