Synthesis and Properties of a Biodegradable Dendritic Magnetic Resonance Imaging Contrast Agent  

作　　者：Tingting Li Yue Qian Mingzhou Ye Jianbin Tang Hongjie Hu Youqing Shen 

机构地区：[1]Key Laboratory of Biomass Chemical Engineering of Ministry of Education, Center for Bionanoengineering, and Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, China [2]Department of Radiology, Sir Run Run Shaw Hospital (SRRSH) of School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310027, China Email: Jianbin Tang ([e-mail]), Hongjie Hu ([e-mail])[*] Jianbin Tang, Key Laboratory of Biomass Chemical Engineering of Ministry of Education, Center for Bionanoengineering, and Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, China, Tel.: [phone], Fax: [phone]Hongjie Hu, Department of Radiology, Sir Run Run Shaw Hospital (SRRSH) of School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310027, China

出　　处：《Chinese Journal of Chemistry》2014年第1期91-96,共6页中国化学（英文版）

基　　金：This work was financially supported by the National Natural Science Foundation of China (Nos.20904046,21174128,and 21090352) and the Qianjiang Talent Program of Zhejiang Province of China (No.2010R10050).

摘　　要：Novel biodegradable dendritic contrast agents (DCAs) based on polyester dendrimers were synthesized and characterized.The DCAs were stable at acidic pH,but hydrolyzed rapidly at physiological pH,which rendered the DCA's long-term Gd3+ retention as low as that of small molecule CAs.Their longitudinal relaxivities of 10.2 to 17.5 L·mmol-1·s-1 were about 2.4 to 4.1 times higher than that of DTPA-Gd,indicating their superior contrast-enhancing capability to the clinically used contrast agent.The in vivo MRI study suggested that the DCA at lower generation (G2-DTPA-Gd) could effectively enhance the MRI of tumor,while the one at higher generation (G5-DTPA-Gd) showed more potential in liver imaging.Novel biodegradable dendritic contrast agents (DCAs) based on polyester dendrimers were synthesized and characterized.The DCAs were stable at acidic pH,but hydrolyzed rapidly at physiological pH,which rendered the DCA's long-term Gd3+ retention as low as that of small molecule CAs.Their longitudinal relaxivities of 10.2 to 17.5 L·mmol-1·s-1 were about 2.4 to 4.1 times higher than that of DTPA-Gd,indicating their superior contrast-enhancing capability to the clinically used contrast agent.The in vivo MRI study suggested that the DCA at lower generation (G2-DTPA-Gd) could effectively enhance the MRI of tumor,while the one at higher generation (G5-DTPA-Gd) showed more potential in liver imaging.

关 键 词：DENDRIMER magnetic resonance imaging BIODEGRADABLE tumor imaging 

分 类 号：TP18[自动化与计算机技术—控制理论与控制工程]