基于弹性网络模型的麦芽糖转运蛋白功能残基的识别  

Identification of Functional Residues in Maltose Transporter with the Elastic Network Model

作　　者：周晓峰[1] 谢小露 张蕾[2] 李春华[2] 楼姣英[3] 刘乃波[1] 丁振山[1] 

机构地区：[1]中日友好医院泌尿外科,北京100029 [2]北京工业大学生命科学与生物工程学院,北京100124 [3]北京中医药大学东方医院,北京100078

出　　处：《高等学校化学学报》2014年第6期1311-1317,共7页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:31171267);北京市教委项目(批准号:KM201310005030);北京市教委科技创新平台项目;吴阶平医学基金(批准号:320.6750.12703)资助~~

摘　　要：基于弹性网络模型的热力学方法,识别出麦芽糖转运蛋白质体系中的关键残基,探讨了麦芽糖转运蛋白内长程协同效应,研究结果有助于更好地理解该转运体系发挥生物学功能的分子机制.Maltose transporter is an important kind of transmembrane transporters with significant biological functions which bears the transportation of intracellular and extracellular maltose molecules. The transport process of maltose molecule accompanies with large scale cooperative motions between different domains of maltose transporter. And these motions involve some key residues that mediate signal transduction and allosteric effects between different regions of the protein. In this study, we identified the key residues in this protein system with the thermodynamic method based on the elastic network model which was developed by our group. On this basis, we explored the long-range synergies within the maltose transporter. These results are helpful to a better understanding the molecular mechanisms of function of transporters.

关 键 词：麦芽糖转运蛋白 弹性网络模型 热力学循环 变构效应 功能残基 

分 类 号：O641[理学—物理化学]