地塞米松、托烷司琼及其联合治疗对预防乳腺癌根治术后恶心呕吐的效果比较  

Comparing the effect of dexamethasone, tropisetron, dexamethasone and tropisetron in preventing nausea and vomiting after radical mastectomy

作　　者：廖完敏[1] 张咸伟[1] 艾玲[1] 刘勇[1] 王鼎[1] 李新华[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院麻醉科,武汉430030

出　　处：《中华实验外科杂志》2014年第6期1314-1315,共2页Chinese Journal of Experimental Surgery

摘　　要：目的比较地塞米松、托烷司琼单独或联合应用预防患者乳腺癌根治术后恶心呕吐（PONV）的效果。方法将89例患者随机分为4组：对照组（Ⅰ组，25例），地塞米松10mg组（Ⅱ组，19例），托烷司琼2mg组（Ⅲ组，20例）和地塞米松10mg＋托烷司琼2mg组（Ⅳ组，25例）。评估4组患者术后恶心呕吐。结果Ⅰ、Ⅱ、Ⅲ、Ⅳ组的恶心发生率分别为32％、21％、20％、16％：呕吐发生率分别为24％、16％、15％、12％，与Ⅰ组比较，Ⅱ、Ⅲ、Ⅳ的术后恶心、呕吐发生率低（P〈0．05），但3组组间比较差异无统计学意义（P〉0．05）。结论地塞米松和托烷司琼在预防乳腺癌根治患者PONV的效果上无明显差异。Objective Compare the effect of dexamethasone, tropisetron, dexamethasone and Tropisetron in preventing nausea and vomiting after radical mastectomy. Methods Eighty-nine patients were divided into four groups ; the control （ group Ⅰ ）, the dexamethasone （ group Ⅱ ）, tropisetron （ group m ）, dexamethasone and tropisctron group （Ⅳ group）. Assess PONV of each group. Results The incidence of nausea was 32% , 21% , 20% , 16% respeotinely; And the incidence of vomiting was 24% , 16%, 15%, 12%. Comparing with the control group, the other three groups had a low incidence of postoperative nausea and vomiting （PONV, P 〈 0. 05）. The three groups, showed no statistical significance. Conclusion No significant difference between the dexamethasone and tropisetron in preventing PONV of patients after radical mastectomy.

关 键 词：术后恶心呕吐 托烷司琼 地塞米松 乳腺癌根治术 

分 类 号：R614[医药卫生—麻醉学]