积雪草总苷缓释片体外释药模型考察  

In Vitro Release Kinetics of Centella Asiatica Sustained Tablets

作　　者：梁泽华[1] 尹丽娜[2] 张雅雯[2] 丁倩芸[1] 王胜浩[2] 

机构地区：[1]浙江中医药大学药学院,浙江杭州310053 [2]浙江省医学科学院,浙江杭州310013

出　　处：《成都中医药大学学报》2014年第2期13-14,25,共3页Journal of Chengdu University of Traditional Chinese Medicine

基　　金：浙江省科技厅项目(编号:2011F10048);浙江省教育厅项目(编号:20071123)

摘　　要：目的:评价积雪草总苷缓释片体外释药行为,并对其释药模型进行考察。方法:以反映积雪草主要药效的指标成分——积雪草苷(Asiaticoside,AS)和羟基积雪草苷(Madecassoside,MS)为指标,采用HPLC方法测定该中药释释片的体外释放度,并采用一级、修正后的Higuchi方程以及Cubic方程对缓释片的体外释放特性进行数学模型拟合。结果:以水为释放介质,该中药缓释片可维持指标成分的缓慢释放;相比较于一级方程和Higuchi方程,与Cubic方程所得到的拟合模型更理想(r=0.9989)。结论:CUBIC方程能较好的描述积雪草总苷缓释片的释药规律。Objective： To study the in vitro release kinetics of Centella Asiatica sustained tablets. Methods： The in vitro re- lease behavior of madecassoside and asiaticoside from the sustained tablets were investigated by RP-HPLC method developed. And first- order equation Higuchi equation, and CUBIC equation were established for studying the in vitro release kinetics. Results ： Compared to Higuchi equation and first-order equation, CUBIC equation was fit the best （ r = 0. 9989） . Conclusion ： In vitro release kinetics of Centella Asiatica sustained tablets could be well characterized by CUBIC equation.

关 键 词：积雪苷总缓释片 高效液相 积雪草总苷 释放模型 

分 类 号：R944.9[医药卫生—药剂学] R283.6[医药卫生—药学]