新型交联方法在生物衍生材料中的应用进展  

RESEARCH PROGRESS OF NOVEL CROSS-LINKING METHODS APPLIED IN BIO-DERIVED MATERIALS

作　　者：笪琳萃[1] 龚梅[1] 王旻[1] 解慧琪[1] 

机构地区：[1]四川大学华西医院再生医学研究中心.干细胞与组织工程研究室,成都610041

出　　处：《中国修复重建外科杂志》2014年第6期777-783,共7页Chinese Journal of Reparative and Reconstructive Surgery

基　　金：国家自然科学基金资助项目(31271058);中国博士后科学基金资助项目(2013M531971);National Natural Science Foundation of China(31271058);Postdoctoral Science Foundation of China(2013M531971)

摘　　要：目的综述新型交联方法在生物衍生材料中的应用与研究进展。方法查阅近年来国内外生物衍生材料交联方法的相关文献,并对其进行总结与分析。结果生物衍生材料的新型交联方法可划分为化学交联法、物理交联法和生物交联法三大类,其适用范围及交联性能因交联机制而异。因此,可根据材料的应用需要选择最适宜的交联方法。一系列研究结果表明,交联后的生物衍生材料可有效应用于组织修复与重建。结论使用新型交联方法制备的生物衍生材料具有优良的生物相容性和组织修复能力、更理想的机械性能和降解性能等。这些方法为材料的交联改性提供更多选择,有助于得到更适用于临床的组织工程产品。Objective To review the research progress of novel cross-linking methods applied in bio-derived materials. Methods The literature about the latest progress in the cross-linking methods of bio-derived materials was reviewed and analyzed. Results The novel cross-linking methods of the bio-derived materials can be divided into chemical methods, physical methods, and biological methods, whose available application and cross-linking properties are greatly depended on their mechanisms. So proper methods should be developed to meet the various application requirements of thematerials. A series of studies shows the feasibility and availability of the cross-linked bio-derived materials in the repair and reconstruction of the tissue. Conclusion Bio-derived materials modified by novel cross-linking methods are proved to obtain excellent biocompatibility and tissue repair ability, better mechanical properties and degradation properties, and so on. Those methods provide researchers more choices to cross-linking materials, which are help to obtain the clinical tissue engineering products.

关 键 词：生物衍生材料 交联方法 交联剂 细胞外基质 

分 类 号：R318.08[医药卫生—生物医学工程]