甲状腺机能减退对血脂水平影响的实验研究  

Experimental study of hypothyroidism effects on blood lipid levels

作　　者：张豪云[1] 巩涛[1] 王跃欣[1] 宁殿宾[1] 曹文庆[1] 张旺[1] 秦莉[1] 

机构地区：[1]河北省人民医院普外一科,石家庄050051

出　　处：《国际外科学杂志》2014年第5期315-318,共4页International Journal of Surgery

摘　　要：目的 观察短期甲减对血脂水平的影响及阿托伐他汀的保护作用.方法 新西兰大白兔60只,随机分成实验组1（甲状腺近全切除＋ ^131I清甲n=20）、实验组2（甲状腺近全切除＋^131 I清甲＋阿托伐他汀干预n=20）、对照组（假甲状腺切除组n=20）.比较各组术前、术后3周和术后5周甲状腺功能和血脂水平变化.结果 （1）与术前相比,两实验组甲状腺功能在术后3周和术后5周均明显降低;（2）手术后随时间延长实验组1 TG、TC、LDL-C水平逐渐升高;术后5周实验组1 HDL-C水平与术前相比明显降低.术后3周和术后5周实验组2 TG水平较术前明显降低;术后3周实验组2 LDL-C水平较术前明显降低.结论 （1）短期甲减可以使血浆TG、TC、LDL-C水平升高;（2）阿托伐他汀可维持短期甲减期间血脂稳定.Objective To observe the effects of short-term withdrawal of thyroxine on lipid level and the protective effect of atorvastatin.Methods The study included 60 rabbits which were randomly divided into treatment experiment group 1 （near-total thyroidectomy ＋ ^131 I ablative therapy）,treatment experiment group 2 （near-total thyroidectomy ＋ ^131I ablative therapy ＋ Atorvastatin intervention） and control group（sham thyroidectomy）.Compared the thyroid functions and lipid levels among different groups at the points of before surgery.three weeks after surgery and five weeks after surgery.Results （1） Compared to before surgery,the thyroid function at the points of three weeks and five weeks after surgery were obvious reduced both in treatment group.（2） The leves of TG,TC,LDL-C in EG1 were increased gradually with the extension of time after surgery.Compared with the point of before surgery,the level of HDL-C at the point of five weeks after surgery was significantly declined in EG1.Compared with the point of before surgery,the level of TG at the ponts of three weeks and five weeks after surgery was significantly declined in EG2.Compared with the point of before surgery,the level of LDL-C at the point of three weeks after surgery was significantly declined in EG2.Conclusions （1） Short-term hypothyroidism can increase the levels of TG,TC,LDL-C in plasma.（2） Atorvastatin can maintain the stability of blood lipids during Short-term hypothyroidism.

关 键 词：短期甲减 血脂 阿托伐他汀 甲状腺近全切除术 ^131I 兔 手术前期 手术后期间 

分 类 号：R653[医药卫生—外科学]