重组乙肝疫苗免疫持久性观察  

The long-term efficacy of recombinant hepatitis B vaccines for children

作　　者：董晓莲[1] 王学才[1] 陈颖峰[1] 陈胜玉[1] 王晓丽[1] 范建良[1] 郑英杰[2] 唐智峰[1] 

机构地区：[1]德清县疾病预防控制中心,浙江德清313200 [2]复旦大学公共卫生学院流行病学教研室

出　　处：《浙江预防医学》2014年第6期548-551,共4页Zhejiang Journal of Preventive Medicine

基　　金：浙江省科技计划项目(2012C33030)

摘　　要：目的：了解儿童重组乙肝疫苗基础免疫与加强免疫后的免疫持久性。方法选择免疫史信息保存完备、婴儿期完成0-1-6月基础免疫的493名中小学生为对象。对所有对象检测抗-HBs等指标，并对是否作加强免疫、不同年龄时间作加强免疫以及距末次免疫接种不同时间的抗-HBs平均水平和达到乙肝免疫保护水平的阳性率作比较，分析乙肝疫苗不同免疫接种情况下的免疫持久性。结果加强免疫组与基础免疫组抗-HBs阳性率分别为91.40%和57.14%，两组比较差异有统计学意义（ P〈0.01）。10μg加强免疫组0-5年后抗-HBs滴度较高，抗体阳性率94.99%；5μg加强免疫组8-15年后抗-HBs滴度较低，抗体阳性率下降至64.71%，与基础免疫组比较差异无统计学意义（ P=0.49）。结论乙肝疫苗加强免疫后可提高抗-HBs阳性率，远期抗-HBs滴度水平和抗体阳性率降低；婴儿期基础免疫3-11年后免疫记忆缺失率低。Objective To observe long-term efficacy of recombinant hepatitis B vaccines for children received fundamental immunization or booster dose. Methods 493 school students from Deqing county with complete information of immunization history were investigated and their serological markers were detected. 430 students received booster dose vaccines at 3-11 years old and were defined as booster group while the remaining 63 students were defined as fundamental group. Results All vaccines the 493 students received for fundamental immunization were recombinant. Compared with fundamental group（57. 14%）,booster group had significantly higher Anti-HBs positive rate of 91. 40%（P〈0. 01）. And the Anti-HBs positive rate had a high level of 94. 99% when 0-5 years after booster immunization while it declined to 64. 71% after 8-15 years and showed no significant difference compared with fundamental group. Conclusion Anti-HBs level and anti -HBs positive rate can significantly increase for short periods after booster immunization,and may decline considerably for long-term. Immunologic amnesia rate is low when 3 -11 years after fundamental immunization among infants.

关 键 词：重组乙肝炎苗 基础免疫 加强免疫 免疫持久性 

分 类 号：R186[医药卫生—流行病学]