高效液相色谱法测定血塞通胶囊中人参皂苷Rg_1、Re、Rb_1、Rd及三七皂苷R_1的含量  

Determination of Ginsenoside Rg_1,Re,Rb_1, Rd and Notoginsenoside R_1 in Xuesaitong capsule by HPLC

作　　者：李慧云[1] 杜秋[1] 温然[1] 徐攀[1] 杜守颖[1] 陆洋[1] 

机构地区：[1]北京中医药大学,北京100102

出　　处：《天津中医药》2014年第6期370-372,共3页Tianjin Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金面上项目(81073057);北京中医药大学复方中药制药研究创新团队(2011-CKTD-13)

摘　　要：[目的]建立血塞通胶囊中5种皂苷的含量测定方法。[方法]采用高效液相色谱法对制剂中的人参皂苷Rg1、Re、Rb1、Rd和三七皂苷R1进行定量测定。[结果]人参皂苷Rg1、Re、Rb1、Rd和三七皂苷R1的线性范围均符合要求,5种皂苷样品回收率均合格,RSD在3.00%以内。[结论]所建立的方法简便、快捷,重复性好,可用于该制剂的质量控制。[Objective] To establish a method for the determination of 5 effective components in Xuesaitong capsule. [Methods] The contents of ginsenoside Rg1, Re, Rb1, Rd and notoginsenoside R1 in Xuesaitong capsule were determined by HPLC. [Results] The resolutions of the determined peaks were fine. The linearity ranges for ginsenoside Rgl, Re, Rbl, Rd and notoginsenoside R1 all met the requirement. The average recoveries of Rg1, Re, Rb1, Rb and Notoginsenoside R1 were qualified, and RSD was less than 3.00%. [Conclusion] The quantitative method for determining the ingredients of Xuesaitong capsule is simple, feasible and repeatable, and is beneficial to quality control of Xuesaitong capsule.

关 键 词：血塞通胶囊 高效液相色谱法 三七总皂苷 含量测定 

分 类 号：R284.1[医药卫生—中药学]