糖尿病患者血浆氧化修饰低密度脂蛋白测定及临床意义  

CLINICAL SIGNIFICANCE OF PLASMA OXIDIZED MODIFIED LOW-DENSITY LIPOP ROTEIN IN PATIENTS WITH DIABETES MELLITUS

作　　者：冯忠军[1] 张淑兰[2] 樊锡风[1] 任启富[1] 

机构地区：[1]河北医科大学第三医院检验科,石家庄050051 [2]石家庄市中医院检验科

出　　处：《河北医科大学学报》2001年第2期93-95,共3页Journal of Hebei Medical University

摘　　要：目的探讨氧化修饰低密度脂蛋白 (oxidizedmodifiedlow -densitylipoprotein ,ox -LDL)在糖尿病患者继发动脉粥样硬化性并发症中的作用和意义。方法采用酶联免疫吸附实验 (ELISA)测定 90例糖尿病患者和 30例健康对照者血浆ox LDL的水平。结果糖尿病患者具有较高水平的ox LDL ,而且 2型糖尿病患者明显高于 1型糖尿病患者 ,有血管并发症者高于无此症者 ,糖尿病病程也可影响ox LDL的水平。LDL的过氧化与血糖控制水平有关。结论ox LDL在糖尿病患者动脉粥样硬化性并发症的发生中起着重要作用。治疗糖尿病的同时适当应用抗氧化剂 。ObjectiveTo explore the significance of plasma oxidized modified low-density lipoprotein (ox LDL) in diabetes mellitus(DM) with atherosclerosis.MethodsThe levels of plasma ox LDL were measured by enzyme link immunoabsorbent assay(ELISA) in 90 patients with DM and 30 controls.ResultsThe plasma ox LDL level in patients with DM was significantly higher than that in normal controls. Type two DM patients showed higher ox LDL level than type one DM patients.Higher ox LDL levels could be found in patients with vascular complications and the patients with longer clinical course.Plasma ox LDL was correlated with fast blood sugar in DM patients.Conclusionox LDL plays an important role in the pathogenesis of atherosclerosis in DM patients.Proper uses of antioxidants may prevent the DM patients from occurance of atherosclerotic complication or slow down the pathological process.

关 键 词：糖尿病 并发症 动脉粥样硬化 脂蛋白 测定 氧化修饰低密度脂蛋白 

分 类 号：R587.1[医药卫生—内分泌]