昂丹司琼对肺癌化疗所致恶心呕吐的预防  

The Effect of Ondansetron in Prevention of Chemotherapy-induced Nausea and Vomitus in Lung Cancer Patients

作　　者：邱栋发[1] 黄窕姮[1] 张招莲[1] 

机构地区：[1]福建省三明市第一医院呼吸内科,365000

出　　处：《医药导报》2001年第3期180-181,共2页Herald of Medicine

摘　　要：目的 :评价单剂昂丹司琼对肺癌化疗所致恶心、呕吐的预防作用。方法 :选择 35例肺癌化疗患者 ,采用自身交替对照的方法 ,观察单次静脉注射昂丹司琼 8mg对化疗所致恶心、呕吐的预防作用。结果 :单剂昂丹司琼对肺癌化疗所致恶心、呕吐的控制率分别为 91.4% ,94.3 % ;甲氧氯普胺的控制率分别为 6 5 .7% ,74.3 % ,两者比较差异显著。结论 :单剂昂丹司琼对肺癌化疗所致恶心、呕吐有明显的预防作用。Objective:To evaluate the effect of single-dose ondansetron in prevention of chemotherapy-induced nausea and vomitus in lung cancer patients. Methods:35 lung cancer patients receiving chemotherapy were observed with self-comparisonal design. A single dose of 8mg ondansetron and of 20mg metoclopramide were administered by intravenous injection and intramuscular in jection to the patients at different time and the outcome was observed. Results:The control rates of nausea and vomitus by ondansetron were 91.4% and 94.3%, and 65.7% and 74.3% by metoclopramide respectively(P<0.05). Conclusion:A single-dose of ondansetron can effectively prevent nausea and vomitus in lung cancer patients caused by chemotherapy.

关 键 词：昂丹司琼 甲氯氯普胺 肺癌 呕吐 药物疗法 化疗 预防 

分 类 号：R975.4[医药卫生—药品] R730.53[医药卫生—药学]