糖肾宝冲剂对糖尿病肾病患者外周血内皮祖细胞及相关炎性因子的影响  

Effects of Tangshenbao Granule on Peripheral Blood Endothelial Progenitor Cells and Related Inflammatory Cytokines in Patients with Diabetic Nephropathy

作　　者：向少伟[1] 向春来 辛立红[3] 黄国东[1] 黄仁发[1] 程新[1] 胡维[1] 

机构地区：[1]广西中医药大学附属瑞康医院,广西南宁530011 [2]湖北省汉川市田二河镇卫生院,湖北汉川431605 [3]广西中医药大学研究生处,广西南宁530011

出　　处：《安徽中医药大学学报》2014年第3期28-31,共4页Journal of Anhui University of Chinese Medicine

基　　金：广西壮族自治区卫生厅中医药科技专项(GZPT1225)

摘　　要：目的观察糖肾宝冲剂对糖尿病肾病(diabetic nephropathy,DN)患者外周血内皮祖细胞(endothelial progenitor cells,EPCs)数量及其增殖能力的影响,探讨其可能的作用机制。方法将92例DN患者,按随机数字表法分为治疗组和对照组,每组46例。对照组采用降血糖、降血压、降血脂等常规治疗,治疗组在对照组疗法基础上加服糖肾宝冲剂,疗程16周。观察两组治疗前后空腹血糖(fasting plasma glucose,FPG)、血清肌酐(serum creatinine,SCr)、尿白蛋白排泄率(urinary albumin excretion rate,UAER)、尿N-乙酰β-D氨基葡萄糖苷酶(N-acetylβ-D-glucosaminidase,NAG),血清超敏C-反应蛋白(high-sensitivity C-reactive protein,hs-CRP)、肿瘤坏死因子-α(tumor necrosis factor,TNF-α)、白细胞介素-6(interleukin,IL-6)水平,以及血清EPCs数量及其增殖能力。结果与治疗前比较,治疗后两组UAER、NAG、hs-CRP、TNF-α及IL-6均显著下降(P<0.01),外周血EPCs数量及其增殖能力均显著升高(P<0.01),但治疗组在改善上述指标方面均显著优于对照组(P<0.01)。结论糖肾宝冲剂能显著提高DN患者外周血EPCs数量及其增殖能力,减轻肾损害,其作用机制可能与抑制DN的炎性反应有关。Objective To observe the effects of Tangshenbao Granule on the number and proliferative capacity of peripheral blood endothelial progenitor ceils （EPCs） and its possible action mechanism in patients with diabetic nephropathy （DN）. Methods Ninety-two DN patients were divided into treatment group （n= 46） and control group （n= 46） using a random number table. Both groups received conventional antidiabetic, antihypertensive, and antihyperlipidemic treatment; additionally, the treatment group received Tangshenbao Granule. The course of treatment was 16 weeks for both groups. The changes in fasting plasma glucose, serum creatinine, urinary albumin excretion rate （UAER）, urinary N-acetyl-β-D-glueosaminidase （NAG）, serum high-sensitivity C-reactive protein （hs-CRP）, tumor necrosis factor-α （TNF- α）, and interleukin-6 （IL-6）, as well as the number and proliferative capacity of sertrm EPCs, were evaluated. Results After treatment, both groups showed significant decreases in UAER, NAG, hs-CRP, TNF- α, and IL-6 （P〈0. 01） and significant increases in the number and proliferative capacity of peripheral blood EPCs （P〈0.01）, and the treatment group showed significantly more improvements in the above in- dices than the control group （P〈0.01）. Conclusion Tangshenbao Granule can significantly increase the number and proliferative capacity of peripheral blood EPCs and reduce renal injury in DN patients, possibly by inhibiting inflammatory response.

关 键 词：糖尿病肾病 糖肾宝 内皮祖细胞 炎性因子 

分 类 号：R587.2[医药卫生—内分泌]