疏肝助化汤联合二甲双胍治疗代谢综合征临床观察  

Combination of “Shugan Zhuhua Deocotion” and metformin hydrochloride for the treatment of metabolic syndrome

作　　者：马俐[1] 陆红[1] 郭亚芳[1] 

机构地区：[1]复旦大学附属浦东医院中医科,上海201399

出　　处：《上海中医药杂志》2014年第5期62-65,共4页Shanghai Journal of Traditional Chinese Medicine

摘　　要：目的观察疏肝助化汤联合二甲双胍治疗代谢综合征的临床疗效。方法将100例代谢综合征患者随机分为治疗组和对照组,每组50例。两组均给予口服二甲双胍肠溶片治疗,并结合饮食控制、适当运动,治疗组加服疏肝助化汤。两组疗程均为2个月,观察临床疗效和不良反应的发生情况,同时比较治疗前后患者的腰围、血压、血糖、胰岛素、胰岛素敏感指数(ISI)及血脂水平的变化情况。结果共有95例患者完成临床观察,治疗组47例,对照组48例。②治疗组、对照组总有效率分别为95.74%、85.41%;组间临床疗效比较,差异有统计学意义(P<0.05)。③治疗前后组内比较,两组腰围、血压(收缩压与舒张压)、血糖(空腹血糖与餐后2 h血糖)、空腹胰岛素、胰岛素敏感指数、血脂(三酰甘油、胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇)水平差异均有统计学意义(P<0.05);组间治疗后比较,相关指标水平差异均有统计学意义(P<0.05)。④治疗组、对照组不良反应总发生率分别为6.38%、22.92%,差异有统计学意义(P<0.05)。结论疏肝助化汤联合二甲双胍治疗代谢综合征疗效满意,不良反应较少,有助于预防糖尿病及心脑血管疾病的发生。Objective To observe the clinical efficacy of ＂Shugan Zhuhua Deoeotion＂ and rnetformin hydroehloride for the treatment of metaholic syndrume. Methods Oue huudred cases with metabolic syndrome were randomly divided into treatment group and control group, with 50 eases in each group. Both groups were treated with metformin hydrochloride enteric coatel tablets orally, and diet controlling, physical exercises. The cases in treatment group were treated with ＂Shugan Zhuhua Deocotion＂, with the course of 2 months. We observed the clinical efficacy and adverse raction, and compared the waistline, blood pressure, blood sugar, insulin, insulin sensitivity index （ ISI）, blood lipid level before and after treatment. Results （1） After treatment, ninety-nine cases were observed, 47 cases in treatment group and 48 cases in control group. （2） The overall effective rate was 95.74% in the treatment group and 85.41% in the control group, with a difference in clinical efficacy between the two groups （P 〈 0.05 ）. （3） In each group, there were significant differences in waistline, blood pressure （ systolic pressure and diastolic pressure） , blood sugar （FBG, 2 h postprandial blood sugar） , FINS, blood fat （TG, cholesterol, HDL-C, LDL-C） between before and alter treatment （ P 〈 0.05 ） ; after treatment, there were significant differences in related indicators between the two groups （P 〈 0.05 ）. （4） The occurrence rate of adverse reation was 6.38% in treatment group and 22.92% in control group, with significant difference between the two groups （ P 〈 0.05）. Conclusion Combined ＂Shngan Zhuhua Deoeotion＂ and metformin hydroehloride has positive effect on metabolic syndrome, with fewer adverse reaetion, and help prevent the diabetes and cardiovascular diseases.

关 键 词：代谢综合征 中西医结合疗法 疏肝助化汤 

分 类 号：R259[医药卫生—中西医结合]