脑苷肌肽注射液治疗新生儿缺氧缺血性脑病的疗效  

Curative Effect of Cattle Encephalon Glycoside and Ignotin Injection on Neonatal Hypoxic-Ischemic Encephalopathy

作　　者：林坚 董战玲[2] 

机构地区：[1]海口市第三人民医院儿科 [2]海南医学院生理学教研室,海口571199

出　　处：《南昌大学学报（医学版）》2014年第4期22-23,30,共3页Journal of Nanchang University：Medical Sciences

基　　金：海南省重点科技项目(061011);海南省教育厅科研资助项目(Hj2007113);海南医学院培育基金(HY2010-005)

摘　　要：目的探讨脑苷肌肽注射液治疗新生儿缺氧缺血性脑病（HIE）的疗效。方法将86例HIE新生儿按随机数字表法分为对照组和治疗组,每组43例。对照组和治疗组在＂三支持、三对症＂治疗的基础上分别给予胞二磷胆碱125mg、脑苷肌肽注射液2mL,均为静脉滴注,1次·d^-1,10-14d为1个疗程。观察2组患儿的疗效（疗效判定指标包括原始反射、意识障碍、肌张力恢复时间及惊厥消失时间）,比较治疗前后新生儿神经行为评分（NBNA）。结果治疗组总有效率（95.3%）高于对照组（72.1%）（P〈0.05）。2组治疗前NBNA评分差异无统计学意义（P〉0.05）;治疗后治疗组NBNA评分[（36.15±2.24）分]高于对照组[（34.28±2.79）分]（P〈0.01）。结论在常规综合治疗的基础上应用脑苷肌肽注射液治疗HIE的疗效优于胞二磷胆碱。Objective To explore the curative effect of cattle encephalon glycoside and ignotin injection on neonatal hypoxic-ischemic encephalopathy（HIE）.Methods Eighty-six neonates with HIE were randomly assigned to intravenously receive either citicoline 125 mg once daily（control group,n=43）or cattle encephalon glycoside and ignotin injection 2 mL once daily（treatment group,n=43）for 10-14 days as a course of treatment based on the “three supports and three symptomatic treatments”.Clinical manifestations （primitive reflexes,conscious disturbance,time to muscle tone recovery,and time to convulsions disappearance）and neonatal behavioral neuro-logical assessment（NBNA）scores were recorded before and after treatment.Results The total effective rate in treatment group was significantly higher than that in control group （9 5 .3% vs 72.1%,P〈0.05）.There were no significant differences in NBNA scores between the two groups before treatment.After treatment,NBNA scores in treatment group were significantly higher than those in control group[（36.15±2.24）vs （34.28±2.79）,P〈0.01）].Conclusion Cattle enceph-alon glycoside and ignotin injection is superior to citicoline for treating HIE based on conventional comprehensive treatment.

关 键 词：脑苷肌肽 胞二磷胆碱 新生儿 缺氧缺血性脑病 

分 类 号：R722[医药卫生—儿科]