清胃败毒方应用于慢性牙周炎急性发作期60例  

Qingwei Baidu Prescription Treatment of 60 Cases of Acute Episode of Chronic Periodontitis

作　　者：付文[1] 易小英[1] 张伟[1] 陈永吉[2] 

机构地区：[1]黄冈市中心医院,湖北黄冈438000 [2]湖北医药学院附属太和医院,湖北十堰442000

出　　处：《中医学报》2014年第6期830-832,共3页Acta Chinese Medicine

基　　金：湖北省十堰市科技局科技攻关项目(编号:20061804)

摘　　要：目的:观察清胃败毒方治疗急性发作期慢性牙周炎的临床疗效。方法:120例慢性牙周炎患者采用随机平均分为对照组和观察组各60例。对照组给予阿奇霉素片,每次0.5 g,每天1次,口服;替硝唑片,每次1.0 g,每天1次。观察组在对照组基础上给予清胃败毒方,每天1剂,常规水煎分2次服用。两组疗程均为7 d。记录治疗前后牙周局部症状,包括牙龈指数(GI)、菌斑指数(PLI)、牙周袋深度(PD)、龈沟出血指数(SBI)及采用VAS评分评价牙龈疼痛程度;检测治疗前后牙齿沟液中肿瘤坏死因子-α(TNF-α)、白细胞介数-6(IL-6)及前列腺E2(PGE2)水平。结果:观察组有效率为91.67%,对照组有效率为78.33%,两组比较,差异有统计学意义(P<0.05);观察组治疗后SBI、PLI、GI、PD及VAS评分均低于对照组(P<0.01);观察组治疗后牙齿沟液TNF-α、IL-6和PGE2水平低于对照组(P<0.01)。结论:清胃败毒方能改善慢性牙周炎急性发作期患者的临床症状,提高临床疗效,其作用机制可能与降低牙齿沟液中炎性因子水平、减轻炎症反应有关。Objective： To observe the clinical effect of Qingwei Baidu Prescription treatment of acute episode of chronic periodontitis.Methods： 120 cases of chronic periodontitis patients were randomly divided into the control group（ n = 60） and the observation group（ n= 60）. The control group was given azithromycin tablets,0. 5 g each time,1 time a day,oral,and tinidazole tablets,1. 0 g each time,once a day. The observation group was given Qingwei Baidu Prescription on the basis of control group,daily 1 agent,conventional decocting,twice. 7 days for a course of treatment of the two groups. Recorded periodontal local symptoms before and after the treatment,including the gingival index（ GI）,plaque index（ PLI）,periodontal pocket depth（ PD）,gingival sulcus bleeding index（ SBI） and used VAS score evaluation to evalue gum pain degree. Detected tumor necrosis factor alpha（ TNF alpha）,Interleukin-6（ IL-6） and prostaglandin E2（ PGE2） levels in tooth groove liquid before and after treatment. Results： Effective rate of the observation group was 91. 67%,the control group was 78. 33%,comparison of two groups showed that the difference was statistically significant（ P〈 0. 05）; after treatment,SBI,PLI,GI and PD,and VAS scores of the observation group were lower than that of control group（ P〈 0. 01）; TNF-α,IL-6 and PGE2levels of the observation group in the tooth groove liquid were lower than that of the control group（ P〈 0. 01）. Conclusion： Qingwei Baidu Prescription can improve the clinical symptoms of chronic periodontitis patients with acute phase,improve the clinical curative effect,its mechanism may be related to lower levels of inflammatory cytokines in tooth groove liquid,reduce inflammation reactions.

关 键 词：慢性牙周炎 清胃败毒方 炎性因子 

分 类 号：R276.881.43[医药卫生—中医五官科学]