系统性红斑狼疮患者的嗅觉功能及其相关因素的研究  

Olfactory function and related factors in systemic lupus erythematosus

作　　者：陈麒麟[1] 李洁[1] 邱凤[1] 宋立军[1] 刘花香[1] 李兴福[1] 

机构地区：[1]山东大学齐鲁医院风湿科,济南250012

出　　处：《中华风湿病学杂志》2014年第6期408-410,共3页Chinese Journal of Rheumatology

基　　金：山东大学青年创新基金（2009TS058）

摘　　要：目的 检测SLE患者的嗅觉功能,并探讨嗅觉功能受损与抗核糖体P蛋白抗体（ARPA）、病程及年龄的关系.方法 采用康涅狄格州化学感受临床研究中心（CCCRC）检测法检测65例SLE患者和50名健康人的嗅觉功能;采用ELISA法检测SLE患者及健康对照组血清中的ARPA水平.采用t检验、单因素方差分析、LSD-t检验、Pearson相关分析、多元线性回归分析和χ^2检验进行统计分析.结果 ①活动组SLE患者CCCRC得分[（62±16）分]低于非活动SLE组[（80±13）分]及健康对照组[（83±12）分],差异均有统计学意义（F=26.52,P均＜0.01）,非活动组和健康对照组之间差异无统计学意义（P=0.226）.②在SLE患者中,ARPA阳性16例（阳性率25％）,阴性49例（阴性率75％）,ARPA阳性组和阴性组CCCRC得分差异有统计学意义[分别为（61±17）分,（74±16）分;t=2.681,P=0.009].③SLE患者CCCRC得分与ARPA血清水平呈线性相关关系（r=-0.327,P=0.008）,与病程无明显相关性（r=0.141,P＞0.05）.多元线性回归分析显示,年龄越大、ARPA水平越高,CCCRC得分越低.结论 活动期SLE患者存在嗅觉功能障碍,年龄和ARPA与嗅觉障碍有一定的相关性.Objective To investigate the olfactory function in patients with systemic lupus erythematosus （SLE） and to explore factors that may influence it.Methods The Connecticut Chemosensory Clinical Research Center （CCCRC） test was carried out in SLE patients and healthy controls for olfactory function testing.ELISA method was used to detect anti-ribosomal P protein antibody in the serum.The statistical methods used in this study including t test,ANOVA,LSD-t test,Pearson correlation analysis,multiple linear regression analysis,andχ^2 test.Results ① The CCCRC scores of the active,inactive group and healthy controls were compared,the difference was statistical significant （F=26.52,P=0.01）.CCCRC score in active SLE group （62±16） was lower than that of the inactive group （80±13） the and the normal control group （83±12） （P〈0.01）,while there was no statistical significant difference between the inactive group and the normal controls （P=0.226）.② CCCRC score was lower in 16 ARPA positive SLE patients （61±17） than 49 negative patients （74±16） （t=2.681,P=0.009）.③ In addition,CCCRC score showed a negative correlation with ARPA serum concentration （r=-0.327,P=0.008）.There was no significant correlation between CCCRC score and disease course （r=0.141,P〉0.05）.④ Multiple linear regression analysis indicated that CCCRC score was associated with age and ARPA.Conclusion SLE patients have olfactory dysfunction and the dys-function is associated with age and ARPA.

关 键 词：红斑狼疮 系统性 嗅觉检测 抗核糖体P蛋白抗体 狼疮活动指数 

分 类 号：R593.241[医药卫生—内科学]