血清降钙素原检测对肝衰竭继发感染的诊断价值  

Diagnostic value of detecting serum procalcitonin in liver failure patients complicated with secondary infection

作　　者：王艳[1] 甘建和[1] 冯婷婷[1] 孙蔚[1] 顾静[1] 

机构地区：[1]苏州大学附属第一医院感染病科,江苏省215006

出　　处：《江苏医药》2014年第11期1274-1276,共3页Jiangsu Medical Journal

基　　金：国家"十二五"科技重大专项(2012ZX10002004-008)

摘　　要：目的探讨检测血清降钙素原(PCT)在肝衰竭继发感染的诊断价值。方法检测20例门诊体检者(A组)、28例慢性肝炎(B组)、28例肝衰竭前期(C组)和66例肝衰竭(D组)患者治疗前后血清PCT、TBil、PT、WBC和超敏C反应蛋白(hsCRP)水平。D组分为D1组(有继发感染,48例)和D2组(无继发感染,18例);D1组又分为D1a组(好转,8例)、D1b组(加重,40例)。对结果进行统计分析。结果 A、B、C和D组治疗前的PCT阳性率值分别为0、14.3%、57.1%和72.7%,组间差异明显(P<0.05)。治疗前,C、D组PCT分别与TBil、PT呈正相关(P<0.05)。PCT、WBC和hsCRP在D1组和D2组、D1a组和D1b组之间均有统计学差异(P<0.05)。结论血清PCT检测有助于肝衰竭继发感染的早期诊断。Objective To investigate the diagnostic value of detecting serum procalcitonin （PCT） in the patients with liver failure complicated with secondary infection. Methods Serum TBil, PT,WBC,and hypersensitive C-reactive protein（hsCRP） were detected before and after treatment in 20 persons from outpatient physical examination（group A）, 28 patients with chronic hepatitis（group B）, 28 patients with pre-liver failure（group C）, 66 patients with liver failure（group D）. The patients in group D were subdivided into D1 （with secondary infection, 48 cases） and D2 （without secondary infection,18 cases）. Of D1 after treatment, 8 cases were improved（group Dla） and 40 cases were deteriorated（group Dlb）. The association between the results and illness state was analyzed. Results The positive rates of PCT before treatment in groups of A, B, C and D were 0, 14.3%, 57.1% and 72.7 %, respectively（P〈0.05）. Serum levels of PCT before treatment were positively correlated with those of TBil and PT in groups of C and D（P〈0. 05）. The differences of PCT,WBC and hsCRP were all significant between groups of D1 and D2 or groups of Dla and Dlb（P〈0. 05）. Conclusion The detection of serum PCT is helpful in early diagnosis of secondary infection in the patients with liver failure.

关 键 词：血清降钙素原 肝衰竭 继发感染 

分 类 号：R512[医药卫生—内科学]