分子影像技术活体示踪治疗心肌梗死干细胞研究进展  

Progresses of molecular imaging techniques for tracking stem cells for in vivo myocardial infarction therapy

作　　者：覃杰[1] 单鸿[1] 

机构地区：[1]中山大学附属第三医院放射科,广东广州510630

出　　处：《中国医学影像技术》2014年第6期934-938,共5页Chinese Journal of Medical Imaging Technology

基　　金：国家自然科学基金青年科学基金(81101096);广东省医学科研基金(B2011102)

摘　　要：近年来干细胞移植治疗心肌梗死取得较大进展,采用分子影像技术示踪干细胞对阐明干细胞治疗心肌梗死机制具有重要作用,是动物实验中验证和优化干细胞移植方案的重要工具。放射性核素、MRI及光学成像等分子影像技术可非侵袭性评估移植干细胞的归宿。本文综述示踪干细胞的分子影像技术的最新进展,探讨各技术的优缺点及其临床适用性。In recent years, great progresses have been made in stem cell therapy for myocardial infarction. Molecular imaging used for tracing stem cells plays a critical role on illuminating the therapeutic mechanism of stem cells, which is an important tool for the validation and optimization of stem cell engrafting strategies in preclinical studies. Radionuclide, MRI and optical imaging strategies can non-invasively evaluate the fate of transplanted stem cells. The novel progresses of molecular imaging were reviewed, and the strengths, limitations and clinical applicability of various imaging techniques were explored in this article.

关 键 词：干细胞 心肌梗死 分子显像 

分 类 号：R445.9[医药卫生—影像医学与核医学] R541.4[医药卫生—诊断学]