HBeAg阳性慢性乙型肝炎不同肝组织炎症与纤维化时期血清HBsAg含量的动力学特点  

Dynamic changes in serum HBsAg levels in HBeAgpositive chronic hepatitis B patients with different liver inflammation grades and fibrosis stages

作　　者：谭雷[1] 吴泽倩[2] 刘婷[3] 高志良[2] 柯伟民[2] 

机构地区：[1]中山大学附属第三医院超声科,广东省广州市510630 [2]中山大学附属第三医院感染科,广东省广州市510630 [3]中山大学附属孙逸仙纪念医院感染科,广东省广州市510236

出　　处：《世界华人消化杂志》2014年第14期2023-2027,共5页World Chinese Journal of Digestology

摘　　要：目的:探讨乙型肝炎病毒e抗原(hepatitis B e antigen,HBeAg)阳性在慢性乙型肝炎(chronichepatitis B,CHB)自然病程中,不同肝组织炎症分级和肝纤维化分期时,血清HBsAg含量的动力学特点.方法:应用电化学发光法检测血清HBsAg含量.各自两两比较在肝组织炎症分级1、2、3和4级的四级之间、肝组织纤维化分期Ⅰ、Ⅱ、Ⅲ和Ⅳ期的四期之间血清HBsAg的含量.结果:HBeAg阳性CHB患者的血清HBsAg含量,在肝组织炎症1、2、3和4级时分别为2998 COI/mL±2515 COI/mL、4064 COI/mL±2468 COI/mL、5513 COI/mL±2390 COI/mL和5736 COI/mL±1838 COI/mL;在肝组织纤维化Ⅰ、Ⅱ、Ⅲ和Ⅳ期时分别为3159COI/mL±2577 COI/mL、4075 COI/mL±2149 COI/mL、5670 COI/mL±2189 COI/mL和5976 COI/mL±2128 COI/mL.血清HBsAg含量在肝组织炎症分级四级之间、肝组织纤维化分期四期之间均存在差异(F=9.986,P<0.000和F=13.955,P<0.000).结论:HBeAg阳性CHB,其血清HBsAg含量随肝组织损伤程度的进展而增加.AIM： To investigate the dynamic changes in serum HBsAg levels in HBeAg-positive chronic hepatitis B patients with different liver histological inflammation grades and hepatic fibrosis stages. METHODS： Serum HBsAg levels in HBeAg-positive chronic hepatitis B patients were detected by electrochemiluminescence. Serum HBsAg levels were compared between patients with grades 1, 2, 3 and 4 liver histological inflammation, and between those with stages 1, 2, 3 and 4 hepatic fibrosis. RESULTS： Serum HBsAg levels in patients with grades 1, 2, 3 and 4 liver histological inflammation were 2998 COI/mL ＋ 2515 COI/mL, 4064 COI/mL ＋ 2468 COI/mL, 5513 COI/mL ＋ 2390 COI/mL and 5736 COI/mL ＋ 1838 COI/mL, respectively; while the values in patients with stages 1, 2, 3 and 4 hepatic fibrosis were 3159 COI/mL ＋ 2577 COI/mL, 4075 COI/mL ＋ 2149 COI/mL, 5670 COI/mL ＋ 2189 COI/mL and 5976 COI/mL ＋ 2128 COI/mL, respectively. There were significant differences in serum HBsAg levels between different liver inflammation grades, as well as between different hepatic fibrosis stages （F= 9.986, P 〈 0.000; F = 13.955, P 〈 0.000）. CONCLUSION： Serum HBsAg levels increase dynamically along with the damage of hepatic tissues in patients with HBeAg-positive chronic hepatitis B.

关 键 词：慢性乙型肝炎 乙型肝炎表面抗原 病理损伤 肝组织炎症 肝纤维化 

分 类 号：R512.62[医药卫生—内科学]