食物特异性IgG抗体检测在儿童慢性消化系统疾病中的应用价值  

Value of food-specific IgG antibody detection in children with chronic digestive system diseases

作　　者：章幽芳[1] 黄清选[1] 

机构地区：[1]浙江省衢州市人民医院儿科,浙江省衢州市324000

出　　处：《世界华人消化杂志》2014年第15期2194-2197,共4页World Chinese Journal of Digestology

摘　　要：目的:探讨食物特异性IgG抗体检测在儿童慢性消化系统疾病中的应用价值.方法:比较106例慢性消化系统疾病患儿(观察组)和106例消化系统正常(对照组)患儿14种食物特异性IgG阳性率、血清食物特异性IgG检测阳性率以及出生后4 mo内喂养方式.结果:两组患儿14种食物特异性IgG阳性率较高的均为鸡蛋(61.32%,18.87%)和牛奶(43.40%,11.32%);观察组患儿牛奶、鸡蛋和大豆阳性率均显著高于对照组(43.40%v11.32%)、(61.32%vs 18.87%)、(11.32%v0.00%),差异具有统计学意义(P<0.05).观察组患儿2种食物阳性、3种及以上食物阳性以及总阳性率均显著高于对照组(34.91%v13.21%)、(15.09%vs 4.72%)、(85.85%v49.06%),差异具有统计学意义(P<0.05).观察组患儿出生后4 mo内母乳喂养率显著低于对照组(43.40%vs 76.42%),人工喂养和混合喂养率均显著高于对照组(8.49%vs 1.89%)、(48.11%v s 21.70%),差异具有统计学意义(P<0.05).结论:食物特异性IgG抗体检测能够发现由食物不良反应所致的慢性消化系统疾病,牛奶和鸡蛋为常见食物特异性IgG阳性食物,早期喂养方式是导致食物不耐受的重要因素.AIM： To explore the value of food-specific IgG antibody detection in children with chronic diseases of the digestive system. METHODS： One hundred and six children with chronic diseases of the digestive system （experiment group） and 106 children without digestive system disorders （control group） were included in this study. The IgG antibodies against 14 types of food were detected, and the positive rate of serum food-specific IgG antibody detection and feeding patterns in 4 mo after birth between the two groups were compared. RESULTS： The positive rates of antibodies against eggs （61.32%, 18.87%） and milk （43.40%, 11.32%） were relatively high in the two groups compared with those against other food. The positive rates of antibodies against milk, eggs and soybean in the experiment group were sig-nificantly higher than those in the control group （43.40% vs 11.32%, 61.32% vs 18.87%, 11.32% vs 0.00%, P 〈 0.05）. The percentages of subjects who were positive for antibodies against 2 or 3 kinds of food as well as the total positive rate in the experiment group were significantly higher than those in the control group （34.91% vs 13.21%, 15.09% vs 4.72%, 85.85% vs 49.06%, P 〈 0.05）. The breast-feeding rate in 4 months after birth in the experiment group was significantly lower than that in the control group （43.40% vs 76.42%, P 〈 0.05）. The rates of artificial feeding and partial breastfeeding in the experiment group were sig- nificantly higher than those in the control group （8.49% vs 1.89%, 48.11% vs 21.70%, P 〈 0.05）. CONCLUSION： Food-specific IgG detection can help identify chronic diseases of the digestive system caused by food. The antibodies against milk and eggs are the most common. Early feeding way is an important factor responsible for food intolerance.

关 键 词：儿童 慢性消化系统疾病 食物特异性IGG 

分 类 号：R725.7[医药卫生—儿科]