不同时期花粉症患者外周血淋巴细胞亚群的数量变化及其临床意义  

Change of lymphocyte subsets in peripheral blood with hay fever patients in different period and its significance

作　　者：刁颖[1] 孙劲旅[1] 汤蕊[1] 顾建青[1] 李挚[1] 

机构地区：[1]中国医学科学院北京协和医学院北京协和医院变态反应科,北京100730

出　　处：《基础医学与临床》2014年第6期824-827,共4页Basic and Clinical Medicine

基　　金：吴阶平医学会基金(320.6750.1292)

摘　　要：目的研究花粉症患者发作期和非发作期外周血淋巴细胞亚群的绝对计数水平及其临床意义。方法用血细胞分析仪和流式细胞仪分析20例花粉症患者发作期和非发作期外周血细胞计数和淋巴细胞亚群。结果与非发作期比较,花粉症患者发作期的外周血嗜酸性、嗜碱性细胞、CD8+CD28+和CD8+CD38+T细胞显著升高(P<0.05),自然杀伤细胞显著降低(P<0.05),B淋巴细胞、T淋巴细胞、CD4+T细胞、CD8+T细胞和CD4+CD28+T细胞无明显变化。结论花粉症患者发作期CD8+CD28+和CD8+CD38+T细胞处于激活状态,在过敏性炎性反应中发挥重要作用。Objective To investigate the change of peripheral blood lymphocytes of hay fever and its relationship with different stages of pathogenesis. Methods The peripheral blood cell counts and lymphocyte subsets of 20 cases hay fever patients in onset and non-onset period were determined by hematology analyzer and flow cytometry. Results The levels of eosinophils, basophils, CD8 ^＋ CD28 ^＋ T cells and CD8 ^＋ CD38 ^＋ T cells were significantly higher （P 〈 0. 05）, NK cells was lower （P 〈 0.05）, and B lymphocytes, T lymphocytes, CD4 ^＋ T cells, CD8 ^＋ T cells and CD4 ^＋ CD28 ^＋ T ceils had no significant change in peripheral blood of hay fever in onset period compared with those in non-onset period. Conclusions Hay fever patients＇ CD8 ^＋ CD28 ^＋ and CD8 ^＋ CD38^＋ T cell might be in a state of immune activation in onset period, play an important role in allergic inflammation.

关 键 词：花粉症 发作期 非发作期 淋巴细胞亚群 

分 类 号：R593.1[医药卫生—内科学]