先天性心脏病经导管封堵术后人体血清镍浓度的变化及其与IL-6、IL-10的关系  

Nickel serum concentrations,IL-6 and IL-10 changes and relationship in patients who underwent transcatheter closure for congenital heart disease

作　　者：李政宁[1] 伍伟锋[2] 

机构地区：[1]柳州市人民医院急诊科,广西柳州545006 [2]广西医科大学第一附属医院心内科

出　　处：《临床心血管病杂志》2014年第6期489-491,共3页Journal of Clinical Cardiology

摘　　要：目的:观察先天性心脏病(先心病)经导管封堵术植入国产封堵器前后血清镍浓度及白细胞介素(IL)-6及IL-10的变化,探讨先心病经导管封堵术植入国产封堵器后血清镍浓度与免疫激活的关系。方法:30例先心病患者,行经导管封堵术植入国产封堵器的房间隔缺损(ASD)或室间隔缺损(VSD),为先心病组。另30例年龄及性别相匹配的正常体检成人作为对照组。检测先心病组经导管封堵术前、术后24h、1个月、3个月、6个月血清镍、IL-6与IL-10浓度,并与对照组进行比较。结果:①先心病组经导管封堵术植入国产封堵器后血清镍浓度升高,到术后1个月达到最高(P<0.05),然后逐渐减低,到6个月回到术前水平;在整个观察期内无过敏反应及毒性反应病例。②经导管封堵术前IL-6与IL-10水平较对照组明显升高(均P<0.05),经导管封堵术后升高,到术后1个月达到最高(P<0.05),然后逐渐减低,到6个月回到对照组水平。③先心病经导管封堵术植入国产封堵器后,在术后1个月血清镍浓度与血清IL-6、IL-10呈正相关(P<0.05)。结论:先心病经导管封堵术植入国产封堵器后血清镍浓度升高,到术后1个月达到最高,然后逐渐减低,到6个月回到术前水平。经导管封堵术后1个月血清镍浓度与免疫激活状况(IL-6、IL-10变化水平)呈正相关关系。Objective：To observe the nickel serum concentrations changes in patients with congenital heat dis- ease after transcatheter closure and research the relationship between nickel serum concentrations and inflammato- ry factor （IL-6, IL-10） in patients with congenital heat disease after transcatheter closure. Method： All 30 patients with congenital heart disease including atrial septal defect （ASD） and ventricle septal defect （VSD） underwent transcatheter closure and 30 healthy control subjects （NC group） were selected for the study. Blood samples for a- nalysis were collected from the patients before the closure and 24 h, 1 month, 3 month, and 6 month after the clo- sure respectively. Nickel serum concentrations and IL-6, IL-10 were assayed. Result：①Mean baseline nickel serum concentrations were within normal range. After occluder implantation, nickel serum concentrations increased over the first month and then decreased to preimplantation levels within 3-6 months. The nickel serum concentrations after occluder implantation was 3-fold higher than baseline （P〈0.05）. ②Before transcatheter closure, the IL-6, IL-10 was significant higher than those in NC group （P 〈 0.05）. After occluder implantation, IL-6 increased over the first month and then decreased to NC group levels within 3-6 months. ③The relationship between nickel ser- um concentrations and IL-6, IL-10 was linear correlation in 1 month after occluder implantation. Conclusion： After occluder implantation, nickel serum concentrations increase over the first month and then decrease to preimplanta- tion levels within 3-6 months. Mean baseline nickel serum concentrations are within normal range. Nickel serum concentrations and immunity activation condition is linear correlation in 1 month after occluder implantation.

关 键 词：先天性心脏病 经导管封堵术 血清镍浓度 白细胞介素-6 白细胞介素-10 

分 类 号：R541.1[医药卫生—心血管疾病]