Toll样受体与特应性皮炎的研究进展  

The research advances of Toll-like receptors and the atopic dermatitis

作　　者：王晓菲[1] 刘军连[2] 司少艳[1] 

机构地区：[1]解放军第306医院中心实验室,北京100101 [2]解放军第306医院皮肤科,北京100101

出　　处：《基础医学与临床》2014年第6期853-856,共4页Basic and Clinical Medicine

基　　金：国家自然科学基金(30872284)

摘　　要：Toll样受体是(TLRs)是目前研究最深入的模式识别受体(PRR),通过识别和结合特异配体,激活信号通路,诱导固有免疫反应,调节获得性免疫反应,在机体的过敏、抗病毒感染、慢性炎性反应中发挥重要作用。特应性皮炎(AD)是一种常见的皮肤病,以剧烈瘙痒、皮肤屏障结构破坏、对病原体易感性增加为特点。本文就TLRs在AD患者中的表达、基因多态性、维生素D(Vit D)通过调控TLRs影响AD的发病,以及TLRs在AD发病机制中的作用进行综述。Toll-like receptor （TLR） is one kind of the most thoroughly studied pattern recogmtlon receptors （PRRs）. TLRs signaling pathways are triggered after recognization of specific ligands. TLRs trigger innate immune responses, prime antigen-specific adaptive immunity and play an important role in the allergy, antivirus activity and chronic inflammation. Atopic dermatitis （AD） is a common skin disease, characterized by severe itching, skin bartier damage, and increased susceptibility of pathogens. Here we describe the recent advances about expressions of TLRs and genetic polymorphisms in AD patients, regulation to TLRs by vitamin D in AD delopment and the role in pathogenesis of AD.

关 键 词：TOLL样受体 特应性皮炎 维生素D 基因多态性 

分 类 号：R758.2[医药卫生—皮肤病学与性病学]