高压氧治疗重型颅脑损伤的疗效及对血清IL-1β和IL-6的影响  

Effects of hyperbaric oxygen on severe craniocerebral injury and serum IL-1β and IL-6

作　　者：刘海鹏[1] 单小松[1] 郑克彬[1] 

机构地区：[1]河北大学附属医院神经外科,保定071000

出　　处：《中国实用神经疾病杂志》2014年第11期52-53,共2页Chinese Journal of Practical Nervous Diseases

摘　　要：目的探讨高压氧疗法对重型颅脑损伤患者的治疗效果,以及对患者血清白介素-1β和白介素-6水平的影响及意义。方法随机将我院收治的164例重型颅脑损伤患者分成治疗组和对照组各82例。所有患者在积极手术的同时,给予脱水降颅压、抗炎、营养脑细胞等药物治疗,待其生命体征趋向平稳后,治疗组给予高压氧治疗。分别于治疗的第1、11、21天测定2组静脉血中IL-1β和IL-6水平,同时在第1、14、180天采用格拉斯哥昏迷量表评定状态。结果治疗组第180天GCS评分12.35±3.69,明显高于对照组的9.84±3.42;治疗组IL-1β水平在第11、21天分别为(268.53±18.42)pg/mL、(127.64±17.54)pg/mL,均低于同期对照组;治疗组和对照组的IL-6水平第11天分别(227.51±18.2l)pg/mL、(287.36±15.48)pg/mL,第21天分别为(90.78±13.93)pg/mL、(100.32±12.27)pg/mL,治疗组血清IL-6水平均显著低于同一时间对照组(P<0.05)。结论高压氧治疗能改善重型颅脑损伤患者的昏迷状态,抑制IL-1β和IL-6的产生和释放,对脑细胞具有保护作用。Objective To explore the therapeutic effect of hyperbaric oxygen therapy on patients with severe craniocerebral injuries ,and its effect on serum interleukin-1β and interleukin-6 levels. Methods One hundred and sixty-four cases of severe craniocerebral injury patients admitted to the hospital were randomly divided into two groups ,namely ,treatment group and control group ,each with 82 cases. While all patients were actively made operation on ,drugs to lower the intracranial pressure , to achieve anti inflammation ,and to nourish brain cells ,were also given. Not until their vital signs became stable were they treated with hyperbaric oxygen. Then the IL-1βand IL-6 level of venous blood were measured in both groups respectively ,on the 1st ,11th ,and 21st day during the treatment ,simultaneously assessment on the consciousness sate of patients on the 1st , 14th ,180th day using the Glasgow coma scale was made.Results The average GCS score of treatment group on the 180th day was （12.35 ± 3.69） ,significantly higher than （9.84 ± 3.42） of control group ,while its IL-1βlevel on the 11th ,and 21st day respectively accounted for （268.53 ± 18.42） pg/mL ,（127.64 ± 17.54） pg/mL ,lower than those of control group. The IL-6 level of both groups were respectively （227.51 ± 18.2l） pg/mL ,（287.36 ± 15.48） pg/mL on the 11th day ,and （90.78 ± 13.93） pg/mL ,（100.32 ± 12.27） pg/mL on the 21st day ,that is ,the average serum IL-6 level of treatment group was obviously lower than that of control group at the same time（P〈0.05）.Conclusion Hyperbaric oxygen therapy can improve the comatose state of patients with severe craniocerebral injuries ,control the producing and releasing of their IL-1βand IL-6 ,and significantly protect their brain cells.

关 键 词：高压氧 白介素-1β(IL-1β) 重型颅脑损伤 白介素-6(IL-6) 

分 类 号：R651.15[医药卫生—外科学]