卡托普利对急性缺血心肌的保护作用  

Protective effects of captopril on myocardium with acute ischemia

作　　者：张福兴[1] 慕春言[2] 高爱玲[1] 

机构地区：[1]焦作市人民医院心内科,河南焦作454002 [2]焦作市第二人民医院心内科,河南焦作454002

出　　处：《河南医学研究》2001年第1期24-25,共2页Henan Medical Research

摘　　要：目的 :研究卡托普利 (Captopril)对急性缺血心肌的保护作用及其可能的抑制。方法 :19只家兔随机分为两组 (对照组n =9,治疗组n =10 ) ,均行冠状动脉左室支中点结扎 10 0分钟 ,观察两组心肌缺血面积、严重室性心律失常发生、血浆去甲肾上腺素 (NE)和血管紧张素Ⅱ (AⅡ )水平的变化。结果 :治疗组心肌缺血面积低于对照组(34.6 %± 2 .2 %vs 40 .8%± 2 .6 % ,P <0 .0 0 1) ,严重室性心律失常发生率在治疗组显著减少 ,且血浆NE、AⅡ水平均明显降低 (P <0 .0 5 )。结论 :卡托普利对急性缺血心肌有保护作用 ,能减少冠脉结扎后缺血心肌面积和室性心律失常的发生 ,其机制与降低血浆NE。Objective: To investigate the protective effects of captopril on myocardium with acute ischemia and its potential mechanisms.Methods: Complete coronary ligation at the middle of left ventricular branch for 100 minutes was carried out in 19 rabbits (control group n=9 ,therapeutic group n=10 ),Ischemic myocardial size,incidence of severe ventricular arrhythmias and plasma levels of norepinephrine(NE) and angiotensin Ⅱ(AⅡ)were measured.Results: Ischemic myocardial size in therapeutic group was lower than in control group (34.6%±2.2% vs 40.8%±2.6%, P<0.001 ),the incidence of severe ventricular arrhythmias and the levels of NE and AⅡ decreased markedly in therapeutic group ( P<0.05 ).Conclusion: Captopril have protective effects on acute ischemic myocardium,decrease ischemic myocardial size and the incidence of ventricular arrhythmias and the mechanism may be related to the reduction in plasma concentrations of NE and AⅡ.

关 键 词：卡托普利 急性心肌缺血 恶性室性心律失常 

分 类 号：R542.205[医药卫生—心血管疾病] R972[医药卫生—内科学]