帕罗西汀联合喹硫平治疗广泛性焦虑障碍的疗效与安全性  

Efficacy and safety of paroxetine combined with quetiapine in the treatment of generalized anxiety disorder

作　　者：张开元[1] 施剑飞[2] 唐光政[2] 陶云海[2] 申变红[2] 赵彤[2] 

机构地区：[1]安徽医科大学医学心理系,合肥230032 [2]安徽医科大学杭州精神卫生临床学院,杭州310013

出　　处：《中国临床药理学杂志》2014年第6期508-510,共3页The Chinese Journal of Clinical Pharmacology

基　　金：杭州市卫生局基金资助项目(2012A038)

摘　　要：目的评价帕罗西汀联合小剂量喹硫平治疗广泛性焦虑障碍的疗效及安全性。方法 140例广泛性焦虑障碍患者随机分为治疗组(帕罗西汀联合小剂量喹硫平,71例)和对照组(帕罗西汀组,69例)。分别于治疗前及治疗后第1,2,4,6,8周末用汉密尔顿焦虑量表(HAMA)评定疗效,治疗副反应量表(TESS)评定药物不良反应,匹兹堡睡眠质量指数(PSQI)进行睡眠状况自评。结果观察8周,治疗组和对照组在治愈率(70.4%/68.1%)、显著改善率(15.5%/13.0%)、进步率(8.5%/10.1%)、无效率(5.6%/8.7%)方面差异无统计学意义(P>0.05)。治疗组在治疗1周末HAMA总分即有明显下降(P<0.05);对照组从2周末开始明显下降(P<0.05)。治疗组1,2,4周末精神焦虑因子较对照组差异有统计学意义(P<0.05或P<0.01);2,4周末躯体焦虑因子分较对照组差异有统计学意义(P<0.05或P<0.01)。治疗后,治疗组与对照组PSQI评分差异有统计学意义(P<0.05或P<0.01)。2组均未发现明显药物不良反应。结论帕罗西汀联合小剂量喹硫平治疗广泛性焦虑症起效早、安全性好,患者依从性好。Objective To investigate the efficacy and safety of paroxetine combined with low dose of quetiapine in the treatment of generalized anxiety disorder. Methods One hundred and forty patients with generalized anxiety disorder were randomly assigned to treatment group （paroxetine combined with low dose of quetiapine group, n = 71 ） and control group （paroxetine group, n -69 ）. The efficacy was assessed by the Hamilton rating scale for anxiety （HAMA）, the Treatment Emergent Symptom Scale（TESS） for side effects, and Pittsburgh sleep quality index （PSQI） for sleep qualities of all participants at baseline and at the end of 1st, 2nd, 4th, 6th, 8thweek. Results There were no significant differ- ences between two groups at cure rate（70. 4%/68. 1% ）, notable improvement rate（ 15.5%/13.0% ） , progress rate （8.5%/10. 1% ）, and ineffective rate （ 5.6%/8.7% ） overall the treatment course. Compare with the baseline, the treatment group showed notable decrease of HAMA at the 1st weekend（P 〈0. 05）, and the control group showed that at the 2nd weekend （P 〈0. 05）. The treatment group had a more significant de- crease than the control group at the 1st, 2nd, and 4th week end（P 〈0. 05 or P 〈 0. 01 ）. The psychic anxiety score of the treatment group at the 1st, 2nd, 4th weekend and the somatic anxiety score at the 2nd, 4th weekend showed significant decrease, compared with the control group （P 〈 00. 05 or P 〈 0.01 ）. Both of the two group had no serious adverse events. Conclusion Paroxetine combined with low dose of quetiapine is an effective and safe way to treat generalized anxiety disorder, and patients have good compliance under the treatment.

关 键 词：广泛性焦虑障碍 帕罗西汀 喹硫平 

分 类 号：R971[医药卫生—药品] R749.4[医药卫生—药学]