小青龙汤对哮喘大鼠肺组织β_2-肾上腺素能受体作用的研究  

STUDY ON THE EFFECT OF XIAOQINGLONG DECOCTION ON PUMONARY TISSUE β_2 AR LEVEL OF RAT WITH ASTHMA

作　　者：童舜华[1] 崔一丽[1] 许建华[1] 

机构地区：[1]上海中医药大学中医基础理论教研室,上海200032

出　　处：《中国中医药科技》2001年第2期77-78,共2页Chinese Journal of Traditional Medical Science and Technology

基　　金：国家中医药管理局资助项目

摘　　要：用卵蛋白 (OA)致敏造成大鼠哮喘模型 ,观察哮喘大鼠肺组织 β -肾上腺素能受体 (βAR)、β2 -肾上腺素能受体 (β2 AR)和环磷酸酰苷 (cAMP)水平的变化及中药小青龙汤对其的影响。结果 :在哮喘激发间隙期和再次激发期 ,模型组大鼠肺组织cAMP均明显低于正常对照组 (P <0 0 1)。在再次激发期 ,小青龙汤等各治疗组肺组织cAMP均明显高于模型组 (P <0 0 5或P <0 0 1)。在间隙期和再次激发期 ,模型组大鼠肺组织 βAR和 β2 AR水平均明显低于正常对照组 (P <0 0 1) ,并且从间隙期到再次激发期有下降趋势。在再次激发期 ,小青龙汤等各治疗组肺组织 βAR和 β2 AR均明显低于正常对照组 (P <0 0 1) ,但除喘康速组外 ,小青龙汤组和必可酮组大鼠肺组织βAR和 β2 AR均显著高于模型组 (P <0 0 5或P <0 0 1)。提示 :小青龙汤能够显著提高哮喘大鼠肺组织βAR、β2The pulmonary tissue β AR、β 2 AR and cAMP levels of asthma attacks of rats a nd the effects of Xiao qinglong Decoction on them were observed.As a result, during the intermission and the second attacking period,the pulmonary tissue βA R、β 2AR and cAMP levels of rats with asthma had been greatly lower than that of the normal control group (P<0 01).From the intermission to the second attac king period,the pulmonary tissue βAR and β 2AR levels of rats with asthma ten ded to decrease.During the second attacking period,after the rats with asthma we re treated with Xiao qinglong Decotion,the βAR and β 2AR and cAMP levels increased greatly (P<0 05 or P<0 01),although the βAR and β 2AR levels w ere greatly lower than that of the normal control group(P<0 01).It was suggest ed that Xiaoqinglong Decoction possesses the action of increasing the pulmo nary tissue βAR、β 2AR and cAMP levels of rats with asthma.

关 键 词：哮喘 中医药疗法 小青龙汤 肺 Β-肾上腺素能受体 

分 类 号：R285.5[医药卫生—中药学]