刺激响应性磁共振成像造影剂的研究进展  

Recent progress in responsive MRI contrast agent

作　　者：汤飞[1] 钟凯[1] 郑新威 

机构地区：[1]中国科学院强磁场科学中心,合肥230031

出　　处：《化工新型材料》2014年第6期4-5,20,共3页New Chemical Materials

基　　金：国家自然科学基金(U1232212);安徽省科学基金(1208085MH132)

摘　　要：目前研究和已临床使用的磁共振成像造影剂一般缺乏特异性,在正常和病灶组织中都发挥作用,使得MRI检测疾病的特异性受到限制。刺激响应性造影剂能够随生理或病理环境的改变而发生弛豫效能和信号强度的改变。因此,刺激响应性造影剂可以作为反应生理条件变化的传感器,应用于生物功能研究和疾病的诊断。介绍了刺激响应性MRI造影剂的种类、结构、机理及其应用发展前景。Presently, MRI contrast agents in study and clinical use generally lack specificity. They play the same role in normal and focal position and therefore the detection of MRI to specific disease is restricted. The responsive contrast a- gents change their relaxation properties and signal strength in response to the physiological or pathological environment change. They can be used as sensors which response to physiological condition change and applied to biomedical research and disease diagnosis. The classifications, structure, mechanism and potential application of several responsive MRI contrast agents will be summarized.

关 键 词：磁共振成像 造影剂 刺激响应性 疾病诊断 

分 类 号：TQ421.7[化学工程]