我国冠心病合并糖尿病治疗临床试验文献的循证医学分析  

The evidence-based medicine analysisabout clinical research literature of coronary heart disease with diabetes in China

作　　者：李战战[1] 薛静[1] 陈立章[1] 

机构地区：[1]中南大学公共卫生学院流行病与卫生统计学系,湖南长沙410078

出　　处：《中国现代医学杂志》2014年第13期55-58,共4页China Journal of Modern Medicine

基　　金：中南大学中央高校基本科研业务费专项资金(No:2012zzts105)

摘　　要：目的分析国内冠心病合并糖尿病治疗临床试验研究文献的质量,为以后临床试验研究提供建议。方法在线检索了有关冠心病合并糖尿病治疗的临床试验文献,并对文献的质量进行评价。结果共纳入137篇研究文献,其中发表在核心期刊57篇,非核心期刊80篇,包括23 820名研究对象,年龄30岁到80岁,病程2年到30年,涉及药物治疗86篇,非药物治疗51篇,5篇为多中心试验,其余均为开放性试验。结论冠心病合并糖尿病治疗的临床研究中单一性研究过多,研究设计不合理,研究方法缺乏创新性,大样本、随机盲法、多中心的研究较少,影响了结论的可信性。我国冠心病合并糖尿病治疗临床试验文献的质量有待提高。对于冠心病合并糖尿病应以综合干预为重,采用个体化治疗方案,在严格控制血糖的基础上全面控制多种危险因素是冠心病合并糖尿病的防治关键。[Objective ] To evaluate the quality of clinical research about treatment of patients with coronary artery disease and diabetes and give advice for clinical trial research. [Methods] Retrieval about treatment of patients with coronary artery disease was conducted in the databases. Each paper was evaluated by evidence-based medicine. [Results] 137 original articles were included, 57 of which was published in the core journals and 80 of which was not. 23 820 subjects aged between 30 and 80 were included. Clinical course was from 2 to 30 years. 86 articles with drug treatment and 51 ones with non-drug treatment were involved.5 articles were muhi-center study and others were open trial. [ Conclusions ] Unity of research in the clinical study, the lack of innovative and unrea- sonable research design without large samples, randomized, blinded, and multi-center study, which affected the credibility of the conclusions. The quality of the clinical trial research needs to be improved. Comprehensive inter- vention and individualized treatment plan should be applied for coronary artery disease with diabetes. The key is that multiple risk factors should be controlled based on the strict control of blood glucose.

关 键 词：冠心病 糖尿病 临床试验 循证医学 

分 类 号：R541.4[医药卫生—心血管疾病] R587.1[医药卫生—内科学]