基于网络药理学的注射用血塞通抗视网膜静脉阻塞作用机制研究  

Network pharmacology study of mechanism on Xuesaitong injection against retinal vein occlusion

作　　者：王林丽[1] 赵筱萍[2] 赵专友[3] 范骁辉[1] 李正[4] 

机构地区：[1]浙江大学中药科学与工程学系,浙江杭州310058 [2]浙江中医药大学基础医学院,浙江杭州310053 [3]天津市药物研究院,天津300193 [4]天津中医药大学天津市现代中药省部共建国家重点实验室,天津300193

出　　处：《中国中药杂志》2014年第12期2322-2325,共4页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(81273991)

摘　　要：视网膜静脉阻塞(RVO)是常见的致盲性眼病,糖尿病、动脉粥样硬化等均能诱导RVO的发生,临床应用表明注射用血塞通对RVO具有良好的治疗效果,但是其作用机制尚不明确。该研究采用大鼠RVO模型,实验证实了血塞通对RVO损伤的保护作用,并通过文献检索建立血塞通抗RVO的成分-靶点网络,并选择性实验验证了血塞通对网络中VEGF,IL-1β和IL-6的作用,阐述了血塞通治疗RVO的多成分多靶点整合调节机制。研究表明注射用血塞通可能通过调控炎症反应、血管生成、细胞凋亡和凝血过程发挥其抗RVO的作用。Retinal vein occlusion（RVO） is a common clinical disease causing vision loss. Risk factors such as diabetes, atherosclerosis are closely associated with RVO. Xuesaitong injection is used extensively in clinical treatment of RVO, however the mechanism is still unclear. In this study, we investigated the protective effect of Xuesaitong injection on RVO rat model. Using a compound-target network of Xuesaitong on anti-RVO constructed by literature mining, we aim to elucidate the multi-compound, multi-target effect of Xuesaitong injection. Fifteen potential targets of Xuesaitong injection associated with inflammation, angiogenesis, apoptosis, and coagulation were identified in this study. VEGF, IL-1β and IL-6, three important targets in the compound-target network were further experimentally validated. This study provided experimental evidence for Xuesaitong injection being effective in treating RVO and a network view on its anti-RVO mode of action through a multi-compound and multiple-target mechanism.

关 键 词：血塞通注射液 视网膜静脉阻塞 网络药理学 多成分多靶点 作用机制 

分 类 号：R285.5[医药卫生—中药学]