人类博卡病毒致成人急性呼吸道感染的临床研究  

Investigation on clinical features of human bocavirus(HBoV) infection in adult acute respiratory infections

作　　者：孙利红[1] 黄象安[1] 杨军勇 杨萧星 王建芳[1] 陈燕力[1] 李安德[1] 王晓才[1] 

机构地区：[1]北京中医药大学东方医院感染科,100078 [2]丰台区疾控中心传染病与地方病防治科

出　　处：《北京医学》2014年第6期444-446,共3页Beijing Medical Journal

摘　　要：目的探讨人类博卡病毒(HBoV)致成人急性呼吸道感染(ARI)的临床特征,分析成人病毒性肺炎与HBoV感染的相关性。方法收集2013年5月至2014年1月在北京中医药大学东方医院感染科发热门诊就诊的81例ARI患者的鼻咽拭子,应用多重RT-PCR及PCR技术进行HBoV、呼吸道合胞病毒(RSV)、腺病毒(ADV)、鼻病毒(RhV)、流感病毒(Flu)、副流感病毒(PIV)、人类偏肺病毒(hMPV)、人冠状病毒(HCoV)、肠道病毒等9种病毒及肺炎支原体、肺炎衣原体的核酸检测,分析HBoV致成人ARI的临床特点。结果 HBoV阳性14例(17.3%),其中10例(71.4%)为肺炎,4例(28.6%)为上呼吸道感染。HBoV单独感染10例,混合感染4例。HBoV感染者咳嗽10例(71.4%),咳嗽伴喘憋1例(7.1%),咯痰6例(42.9%),发热14例(100.0%),肺部闻及湿性啰音者4例(28.6%)。外周血白细胞正常或降低者11例(78.6%),升高者3例(21.4%)。10例肺炎患者胸部X线片表现为斑片状模糊影9例,大片致密影1例。单侧肺炎7例,双侧肺炎3例,病变均位于中下肺叶。重症肺炎1例,为HBoV混合感染ADV及肺炎支原体。结论 HBoV是引起成人ARI的病原体之一,感染部位以下呼吸道为主。Objective To investigate the clinical features of HBoV infection in adult patients with acute respiratory infections. Methods The secretion specimens of deep nasal pharynx were collected from 81 patients with acute respiratory infections during May, 2013 to Janurary, 2014. By multiplex RT-PCR and PCR ,HBoV, respiratory syncytial virus （RSV）, adenovirus, rhinovirus, influenza virus A and B, para-influenza virus, human metapneumovirus, human coronavirus, enteric virus, mycoplasma and chlamydia were tested. The clinical features of patients with HBoV infection were analyzed. Results Fourteen cases were found with positive human bocavirus, the detective rate was 17.3%. Among them, 10 cases （71.4%） were pneumonia, the other 4 cases （28.6%） were upper respiratory infections. In 10 cases （71.4%）, HBoV was the only pathogen detected.The rate of co-infection of HBoV and adenovirus or mycoplasma or influenza virus was 28.6%. The main clinical features included cough （71.4%）, wheezing（7.1%）, sputum（42.9%）and fever（100.0%）. Four（28.6%） cases were found with moist rales. Normal or decreased leukocytes count occurred in 11 cases （78.6%）. There was patchy shadows on X-ray in 10 （71.4%） pneumonia patients. Only 1 patient who got co-infection of HBoV, adenovirus and mycoplasma had severe pneumonia. Conculsion HBoV is one of the viral pathogens in adult with respiratory infection.Most of HBoV can cause low respiratory tract infection.

关 键 词：人类博卡病毒 成人 急性呼吸道感染 临床特征 

分 类 号：R56[医药卫生—呼吸系统]