增液汤颗粒对便秘小鼠的润肠通便作用  

Bowel-lubricating and Defecation-promoting Effects of Zengyetang Granule in Constipation Mice

作　　者：付书婕[1] 农慧亮[1] 王绍龙[1] 龙翊婷[1] 蒋伟哲[1] 

机构地区：[1]广西医科大学药学院,南宁530021

出　　处：《中国现代应用药学》2014年第6期658-662,共5页Chinese Journal of Modern Applied Pharmacy

基　　金：广西科学研究与技术开发计划项目(桂科能0992028-4);广西教育厅校地校企共建科技创新平台项目(桂教科研[2011]9号);广西高校科技创新平台建设项目(桂教科研[2013]8号-4);广西壮族自治区卫生厅中医药科技专项(GZZL14-16)

摘　　要：目的研究增液汤颗粒的润肠通便作用。方法采用复方地芬诺酯建立小鼠便秘模型,观察便秘小鼠的粪便排泄情况、肠水分和小肠推进运动等指标;观察正常小鼠的大肠推进运动;采用在体肠管实验法研究正常大鼠回肠收缩活动和对正常小鼠肠道肠液分泌量的影响。结果增液汤颗粒能够缩短便秘小鼠首次排便时间,增加便秘小鼠粪便粒数(P<0.05或P<0.01),改善粪便性状,增加便秘小鼠肠水分(P<0.05或P<0.01),增强便秘小鼠的小肠推进运动,增强正常小鼠的大肠推进运动,促进正常大鼠回肠收缩,增加正常小鼠肠腔液体量(P<0.05或P<0.01)。结论增液汤颗粒具有较好的润肠通便作用,能够有效治疗便秘。OBJECTIVE To investigate the effect of Zengyetang granule on lubricating bowel and promoting defecation in mice. METHODS The condition of feces excretion, the moisture of intestines, and the intestinal propulsion in mice administered with Compound Diphenoxylate to develop a constipation model were observed. The large intestinal propulsion in normal mice were observed. The contractile activity of ileum in normal rats and the effect of intestinal juice secretion of intestinal canal in normal mice were studied in vivo. RESULTS Zengyetang granule could shorten the time of discharging the first stool, increase the defecate amounts（P〈0.05 or P〈0.01）, improve the stool properties, increase the moisture of intestines（P〈0.05 or P〈0.01）, and enhance the intestinal propulsive rate in constipation mice. Zengyetang granule also could enhance the large intestinal propulsive rate in normal mice, promote the contractile activity of ileum in normal rats, and increase the amount of intestinal canal fluid in normal mice （P〈0.05 or P〈0.01）. CONCLUSION The Zengyetang granule has the action of lubricating bowel and promoting defecation, and can be used for the treatment of constipation.

关 键 词：增液汤颗粒 润肠通便 便秘 

分 类 号：R285.5[医药卫生—中药学]